Barakat Amr F, Saad Marwan, Abuzaid Ahmed, Mentias Amgad, Mahmoud Ahmed, Elgendy Islam Y
Ann Thorac Surg. 2016 Feb;101(2):818-25. doi: 10.1016/j.athoracsur.2015.09.070.
Coronary artery bypass grafting is associated with an intense systemic inflammatory response, which is linked to postoperative complications. Beyond lipid lowering, statins exert a constellation of beneficial actions, including an antiinflammatory role, known as pleiotropic effects. There is increasing evidence that perioperative statin therapy improves outcomes in patients undergoing coronary artery bypass grafting. Statins are underused in the coronary artery bypass grafting population, because perioperative discontinuation remains a common practice. This article provides an extensive review of the available literature on the effect of perioperative statin therapy on post–coronary artery bypass grafting outcomes and weighs the evidence for the concerns about increased incidence of statin-related adverse effects in this setting.
冠状动脉搭桥术与强烈的全身炎症反应相关，而这种反应与术后并发症有关。除了降低血脂外，他汀类药物还具有一系列有益作用，包括抗炎作用，即所谓的多效性。越来越多的证据表明，围手术期他汀类药物治疗可改善接受冠状动脉搭桥术患者的预后。他汀类药物在冠状动脉搭桥术人群中的使用不足，因为围手术期停药仍然是一种常见做法。本文对关于围手术期他汀类药物治疗对冠状动脉搭桥术后预后影响的现有文献进行了广泛综述，并权衡了在这种情况下对他汀类药物相关不良反应发生率增加的担忧的证据。
