Brunner David O, Furrer Lukas, Weiger Markus, Baumberger Werner, Schmid Thomas, Reber Jonas, Dietrich Benjamin E, Wilm Bertram J, Froidevaux Romain, Pruessmann Klaas P
Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
ZSN Center for Signal Processing and Communications, School of Engineering, Zurich University of Applied Sciences, Winterthur, Switzerland.
J Magn Reson. 2016 Feb;263:147-155. doi: 10.1016/j.jmr.2015.12.016. Epub 2016 Jan 4.
For direct NMR detection and imaging of compounds with very short coherence life times the dead time between radio-frequency (RF) pulse and reception of the free induction decay (FID) is a major limiting factor. It is typically dominated by the transient and recovery times of currently available transmit-receive (T/R) switches and amplification chains. A novel PIN diode-based T/R switch topology is introduced allowing for fast switching by high bias transient currents but nevertheless producing a very low video leakage signal and insertion loss (0.5dB). The low transient spike level in conjunction with the high isolation (75dB) prevent saturation of the preamplifier entirely which consequently does not require time for recovery. Switching between transmission and reception is demonstrated within less than 1μs in bench tests as well as in acquisitions of FIDs and zero echo time (ZTE) images with bandwidths up to 500kHz at 7T. Thereby the 2kW switch exhibited a rise-time of 350ns (10-99%) producing however a total video leakage of below 20mV peak-to-peak and less than -89dBm in-band. The achieved switching time renders the RF pulse itself the dominant contribution to the dead time in which a coherence cannot be observed, thus making pulsed NMR experiments almost time-optimal even for compounds with very short signal life times.
对于具有非常短的相干寿命的化合物进行直接核磁共振检测和成像时,射频(RF)脉冲与自由感应衰减(FID)接收之间的死时间是一个主要限制因素。它通常由当前可用的发射 - 接收(T/R)开关和放大链的瞬态及恢复时间主导。本文介绍了一种基于PIN二极管的新型T/R开关拓扑结构,它允许通过高偏置瞬态电流实现快速切换,但仍能产生非常低的视频泄漏信号和插入损耗(0.5dB)。低瞬态尖峰电平与高隔离度(75dB)相结合,完全防止了前置放大器饱和,因此无需恢复时间。在台架测试以及7T场强下带宽高达500kHz的FID和零回波时间(ZTE)图像采集过程中,传输和接收之间的切换在不到1μs的时间内即可完成。在此过程中,2kW的开关上升时间为350ns(10 - 99%),但其总视频泄漏峰峰值低于20mV,带内低于 - 89dBm。所实现的切换时间使得RF脉冲本身成为死时间的主要贡献因素,在此期间无法观测到相干性,因此即使对于信号寿命非常短的化合物,脉冲核磁共振实验几乎也是时间最优的。