哮喘患儿血清白细胞介素-33升高且与疾病严重程度相关。

Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity.

作者信息

Bahrami Mahneh Sedigheh, Movahedi Masoud, Aryan Zahra, Bahar Mohammad Ali, Rezaei Arezou, Sadr Maryam, Rezaei Nima

机构信息

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Int Arch Allergy Immunol. 2015;168(3):193-6. doi: 10.1159/000442413. Epub 2016 Jan 21.

DOI:10.1159/000442413

PMID:26797312

Abstract

BACKGROUND

The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood.

OBJECTIVES

This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity.

METHODS

This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between children with asthma and controls. In addition, the association of serum IL-33 with asthma severity was investigated.

RESULTS

The level of serum IL-33 was significantly higher in children with asthma than in controls (15.17 ± 32.3 vs. 0.61 ± 2.16 pg/ml; p = 0.028). It was significantly increased proportionately to asthma severity, namely 9.92 ± 30.26 pg/ml in children with mild asthma, 13.68 ± 29.27 pg/ml in children with moderate asthma and 31.92 ± 41.45 pg/ml in children with severe asthma (p = 0.026).

CONCLUSION

Serum IL-33 is increased in children with asthma and is associated with disease severity.

摘要

背景

白细胞介素-1家族成员白细胞介素-33（IL-33）在气道高反应性和哮喘中的作用仍有待充分了解。

目的

本研究旨在调查哮喘患儿血清IL-33水平及其与哮喘严重程度的关系。

方法

这项年龄和性别匹配的病例对照研究包括61例哮喘患儿和63例健康对照。参与者的平均年龄为9.21岁（范围：6 - 14岁）。采用酶联免疫吸附测定法（ELISA）检测血清IL-33水平，并在哮喘患儿和对照组之间进行比较。此外，还研究了血清IL-33与哮喘严重程度的关系。

结果

哮喘患儿血清IL-33水平显著高于对照组（15.17±32.3对0.61±2.16 pg/ml；p = 0.028）。其水平随哮喘严重程度成比例显著升高，即轻度哮喘患儿为9.92±30.26 pg/ml，中度哮喘患儿为13.68±29.27 pg/ml，重度哮喘患儿为31.92±41.45 pg/ml（p = 0.026）。