Xuejuan Zhang, Jietao Zhang, Di Han, Yu Zheng, Xiaozi Guo, Yunfa Li, Lihua Dong
General Medicine, Affiliated Hospital of Qingdao University, Qingdao 266031, China.
Department of Neurology, Rizhao People's Hospital, Rizhao 276826, China.
Evid Based Complement Alternat Med. 2015;2015:527219. doi: 10.1155/2015/527219. Epub 2015 Dec 22.
To explore the protective effects of Danhong injection against cerebral damage during on-pump coronary artery bypass graft surgery and its mechanism. Methods. Fifty patients scheduled for on-pump CABG surgery were randomly divided into Danhong injection group (group D) and control group (group C). Group D was given Danhong injection while group C was given the same volume of normal saline when the artery was cut open. Jugular bulb blood right before the operation began (T1), when body temperature rewarming to 36°C (T2), 30 min after the termination of cardiopulmonary bypass (T3), and 6 hrs after the termination of CPB (T4) was collected. The superoxide dismutase activity by using xanthine oxidase method and concentration determination of malondialdehyde were examined. Results. In group C, SOD activity was less at T2-T4 than at T1. It was also less active comparatively in group D at T2-T4. The MDA concentration increased in both groups but was more obvious in group C. Levels of TNF-α, IL-6, IL-8, and IL-10 increased in both groups C and D at T3 and T4, compared to T1. Conclusions. Danhong injection shows significant protective effects against cerebral damage during on-pump coronary artery bypass graft surgery.
探讨丹红注射液在体外循环冠状动脉搭桥手术中对脑损伤的保护作用及其机制。方法。将50例计划行体外循环冠状动脉搭桥手术的患者随机分为丹红注射液组（D组）和对照组（C组）。D组给予丹红注射液，C组在切开动脉时给予相同体积的生理盐水。分别于手术开始前（T1）、体温复温至36℃时（T2）、体外循环结束后30分钟（T3）和体外循环结束后6小时（T4）采集颈静脉球血。采用黄嘌呤氧化酶法检测超氧化物歧化酶活性，测定丙二醛浓度。结果。C组T2 - T4时超氧化物歧化酶活性低于T1时，D组T2 - T4时超氧化物歧化酶活性相对也较低。两组丙二醛浓度均升高，但C组更明显。与T1相比，C组和D组在T3和T4时肿瘤坏死因子-α、白细胞介素-6、白细胞介素-8和白细胞介素-10水平均升高。结论。丹红注射液在体外循环冠状动脉搭桥手术中对脑损伤具有显著的保护作用。
