Robertson Chadia L, Srivastava Jyoti, Rajasekaran Devaraja, Gredler Rachel, Akiel Maaged A, Jariwala Nidhi, Siddiq Ayesha, Emdad Luni, Fisher Paul B, Sarkar Devanand
Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Department of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Hepat Oncol. 2015;2(3):303-312. doi: 10.2217/hep.15.10.
AEG-1 is an oncogene that is overexpressed in all cancers, including hepatocellular carcinoma. AEG-1 plays a seminal role in promoting cancer development and progression by augmenting proliferation, invasion, metastasis, angiogenesis and chemoresistance, all hallmarks of aggressive cancer. AEG-1 mediates its oncogenic function predominantly by interacting with various protein complexes. AEG-1 acts as a scaffold protein, activating multiple protumorigenic signal transduction pathways, such as MEK/ERK, PI3K/Akt, NF-κB and Wnt/β-catenin while regulating gene expression at transcriptional, post-transcriptional and translational levels. Our recent studies document that AEG-1 is fundamentally required for activation of inflammation. A comprehensive and convincing body of data currently points to AEG-1 as an essential component critical to the onset and progression of cancer. The present review describes the current knowledge gleaned from patient and experimental studies as well as transgenic and knockout mouse models, on the impact of AEG-1 on hepatocarcinogenesis.
AEG-1是一种癌基因，在包括肝细胞癌在内的所有癌症中均过度表达。AEG-1通过增强增殖、侵袭、转移、血管生成和化疗耐药性（这些都是侵袭性癌症的特征），在促进癌症发展和进展中发挥着重要作用。AEG-1主要通过与各种蛋白质复合物相互作用来介导其致癌功能。AEG-1作为一种支架蛋白，激活多种促肿瘤信号转导途径，如MEK/ERK、PI3K/Akt、NF-κB和Wnt/β-连环蛋白，同时在转录、转录后和翻译水平上调节基因表达。我们最近的研究表明，炎症激活从根本上需要AEG-1。目前，大量全面且有说服力的数据表明，AEG-1是癌症发生和发展的关键必需成分。本综述描述了从患者和实验研究以及转基因和基因敲除小鼠模型中获得的关于AEG-1对肝癌发生影响的现有知识。
