诺贝尔演讲。化疗的嘌呤之路。
Nobel Lecture. The purine path to chemotherapy.
作者信息
Elion G B
机构信息
Wellcome Research Laboratories, Burroughs Wellcome Co., Research Triangle Park, NC 27709.
出版信息
Biosci Rep. 1989 Oct;9(5):509-29. doi: 10.1007/BF01119794.
PMID:2679902
Abstract
Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.
摘要
嘌呤代谢的抗代谢物已被用作抗白血病、抗原生动物和抗病毒药物，用于免疫抑制和移植，以及痛风和高尿酸血症的治疗。本文对其作用机制进行了综述。
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