生发中心反应、记忆 B 细胞和浆细胞形成的调控——最新进展。
Regulation of germinal center responses, memory B cells and plasma cell formation-an update.
机构信息
Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia.
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia.
出版信息
Curr Opin Immunol. 2016 Apr;39:59-67. doi: 10.1016/j.coi.2015.12.008. Epub 2016 Jan 20.
Progress in understanding humoral immunity has been accelerated by the powerful experimental approaches of genetics, genomics and imaging. Excellent reviews of these advances appeared in 2015 in celebration of the 50th anniversary of the discovery of B cell and T cell lineages in the chicken. Here we provide a contemporary model of B cell differentiation, highlighting recent publications illuminating germinal center (GC), memory B cell and antibody-secreting plasma cell biology. The important contributions of CD4T cells to antibody responses have been thoroughly reviewed elsewhere.
理解体液免疫的进展得益于遗传学、基因组学和成像技术等强大的实验方法。在庆祝鸡 B 细胞和 T 细胞谱系发现 50 周年之际，2015 年发表了这些进展的精彩综述。在这里，我们提供了一个当代的 B 细胞分化模型，重点介绍了最近阐明生发中心（GC）、记忆 B 细胞和分泌抗体浆细胞生物学的出版物。CD4T 细胞对抗体反应的重要贡献已在其他地方进行了全面综述。
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