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Dynamics of B cells in germinal centres.

作者信息

De Silva Nilushi S, Klein Ulf

机构信息

Herbert Irving Comprehensive Cancer Center and Departments of Pathology and Cell Biology, and Microbiology and Immunology, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.

出版信息

Nat Rev Immunol. 2015 Mar;15(3):137-48. doi: 10.1038/nri3804. Epub 2015 Feb 6.

DOI:10.1038/nri3804
PMID:25656706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4399774/
Abstract

Humoral immunity depends on the germinal centre (GC) reaction during which somatically mutated high-affinity memory B cells and plasma cells are generated. Recent studies have uncovered crucial cues that are required for the formation and the maintenance of GCs and for the selection of high-affinity antibody mutants. In addition, it is now clear that these events are promoted by the dynamic movements of cells within and between GCs. These findings have resolved the complexities of the GC reaction in greater detail than ever before. This Review focuses on these recent advances and discusses their implications for the establishment of humoral immunity.

摘要

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本文引用的文献

[1]
Germinal centres and B cell lymphomagenesis.

Nat Rev Immunol. 2015-3

[2]
T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction.

Nature. 2014-10-15

[3]
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J Exp Med. 2014-10-20

[4]
IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

J Exp Med. 2014-9-22

[5]
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J Exp Med. 2014-9-22

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Cell Rep. 2014-9-11

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Science. 2014-8-29

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Immunol Rev. 2014-9

[9]
miR-217 is an oncogene that enhances the germinal center reaction.

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Proc Natl Acad Sci U S A. 2014-5-19

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