生发中心B细胞的动态变化
Dynamics of B cells in germinal centres.
作者信息
De Silva Nilushi S, Klein Ulf
机构信息
Herbert Irving Comprehensive Cancer Center and Departments of Pathology and Cell Biology, and Microbiology and Immunology, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.
出版信息
Nat Rev Immunol. 2015 Mar;15(3):137-48. doi: 10.1038/nri3804. Epub 2015 Feb 6.
Abstract
Humoral immunity depends on the germinal centre (GC) reaction during which somatically mutated high-affinity memory B cells and plasma cells are generated. Recent studies have uncovered crucial cues that are required for the formation and the maintenance of GCs and for the selection of high-affinity antibody mutants. In addition, it is now clear that these events are promoted by the dynamic movements of cells within and between GCs. These findings have resolved the complexities of the GC reaction in greater detail than ever before. This Review focuses on these recent advances and discusses their implications for the establishment of humoral immunity.
摘要
体液免疫依赖于生发中心（GC）反应，在此过程中会产生体细胞高频突变的高亲和力记忆B细胞和浆细胞。最近的研究揭示了生发中心形成和维持以及高亲和力抗体突变体选择所需的关键线索。此外，现在很清楚，这些事件是由生发中心内和生发中心之间细胞的动态运动所促进的。这些发现比以往任何时候都更详细地解析了生发中心反应的复杂性。本综述重点关注这些最新进展，并讨论它们对体液免疫建立的影响。
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