Sánchez-Tena Susana, Cubillos-Rojas Monica, Schneider Taiane, Rosa Jose Luis
Departament de Ciències Fisiològiques II, Campus de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Universitat de Barcelona, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Cell Mol Life Sci. 2016 May;73(10):1955-68. doi: 10.1007/s00018-016-2139-8. Epub 2016 Jan 22.
The HERC gene family encodes proteins with two characteristic domains in their sequence: the HECT domain and the RCC1-like domain (RLD). In humans, the HERC family comprises six members that can be divided into two groups based on their molecular mass and domain structure. Whereas large HERCs (HERC1 and HERC2) contain one HECT and more than one RLD, small HERCs (HERC3-6) possess single HECT and RLD domains. Accumulating evidence shows the HERC family proteins to be key components of a wide range of cellular functions, including neurodevelopment, DNA damage repair, cell growth and immune response. Considering the significant recent advances made regarding HERC functionality, an updated review summarizing the progress is greatly needed at 10 years since the last HERC review. We provide an integrated view of HERC function and go into detail about its implications for several human diseases such as cancer and neurological disorders.
HERC基因家族编码的蛋白质在其序列中具有两个特征结构域：HECT结构域和RCC1样结构域（RLD）。在人类中，HERC家族由六个成员组成，根据它们的分子量和结构域结构可分为两组。大型HERC（HERC1和HERC2）包含一个HECT结构域和多个RLD结构域，而小型HERC（HERC3 - 6）则具有单个HECT和RLD结构域。越来越多的证据表明，HERC家族蛋白是多种细胞功能的关键组成部分，包括神经发育、DNA损伤修复、细胞生长和免疫反应。鉴于最近在HERC功能方面取得的重大进展，自上次关于HERC的综述发表10年来，非常需要一篇更新的综述来总结这些进展。我们提供了HERC功能的综合观点，并详细阐述了其对几种人类疾病（如癌症和神经疾病）的影响。
