Garcia-Gonzalo F R, Rosa J L
Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, L'Hospitalet de Llobregat, Universitat de Barcelona, Spain.
Cell Mol Life Sci. 2005 Aug;62(16):1826-38. doi: 10.1007/s00018-005-5119-y.
HERC proteins are defined as containing both HECT and RCC1-like domains in their amino acid sequences. Six HERC genes have turned up in the human genome which encode two different sorts of polypeptides: while the small HERC proteins possess little more than the two aforementioned domains, the large ones are giant proteins with a plethora of potentially important regions. It is now almost 10 years since the discovery of the first family member and information is starting to accumulate pointing to a general role for these proteins as ubiquitin ligases involved in membrane-trafficking events. In this review, the available data on these six members are discussed, together with an account of their evolution.
HERC蛋白的定义是其氨基酸序列中同时包含HECT结构域和RCC1样结构域。人类基因组中已发现六个HERC基因，它们编码两种不同类型的多肽：小型HERC蛋白除了上述两个结构域外几乎没有其他结构域，而大型HERC蛋白则是具有大量潜在重要区域的巨型蛋白。自发现第一个家族成员至今已近10年，有关这些蛋白作为参与膜运输事件的泛素连接酶的普遍作用的信息开始积累。在这篇综述中，我们将讨论关于这六个成员的现有数据，并对它们的进化进行阐述。
