儿科中罕见的原发性中枢神经系统肿瘤
Rare Primary Central Nervous System Tumors Encountered in Pediatrics.
作者信息
Kramer Kim
机构信息
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
出版信息
J Child Neurol. 2016 Oct;31(12):1394-8. doi: 10.1177/0883073815627878. Epub 2016 Jan 22.
Abstract
As part of the special issue on Pediatric Neuro-Oncology, this article will focus on 4 of the rarer tumors in this spectrum, including atypical teratoid rhabdoid tumors, embryonal tumors with multilayered rosettes, choroid plexus tumors, and pleomorphic xanthoastrocytoma. Incidence and current understanding of the molecular pathogenesis of these tumors are discussed, and avenues of therapy both current and prospective are explored.
摘要
作为小儿神经肿瘤学特刊的一部分，本文将聚焦于该领域中4种较为罕见的肿瘤，包括非典型畸胎样横纹肌样瘤、伴有多层菊形团的胚胎性肿瘤、脉络丛肿瘤和多形性黄色星形细胞瘤。文中讨论了这些肿瘤的发病率及目前对其分子发病机制的认识，并探讨了当前及未来的治疗途径。
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Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children.阿利塞替布作为单一药物对4名儿童复发性非典型畸胎样横纹肌样瘤有效。
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Rare primary central nervous system tumors.罕见的原发性中枢神经系统肿瘤。
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CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.具有C19MC扩增和/或LIN28表达的中枢神经系统原始神经外胚层肿瘤构成一个独特的组织发生学、诊断和治疗实体。
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