English J S, Bunker C B, Ruthven K, Dowd P M, Greaves M W
Clin Exp Dermatol. 1989 Jan;14(1):32-4. doi: 10.1111/j.1365-2230.1989.tb00879.x.
A total of 97 out-patients with steroid responsive dermatoses (63 eczema, 34 psoriasis) were recruited from two centres. They were randomly allocated in a double-blind manner to receive either betamethasone dipropionate cream twice daily or betamethasone dipropionate cream in the morning and base cream in the evening. The treatment period was 3 weeks. Eighty-five patients completed the study. There were no statistical differences between once daily application and twice daily for all of the parameters studied in both the eczema and psoriasis patients. Analysis of the diary card records, however, showed that symptomatic relief occurred more quickly in eczema patients receiving twice daily application of betamethasone dipropionate cream (P = 0.03). The use of betamethasone dipropionate cream once daily in conjunction with an emollient provides a regime which is as effective as a twice daily application of betamethasone dipropionate.
从两个中心招募了总共97例对类固醇有反应的皮肤病门诊患者（63例湿疹患者，34例银屑病患者）。他们以双盲方式随机分配，分别接受每日两次的丙酸倍他米松乳膏治疗，或早晨使用丙酸倍他米松乳膏、晚上使用基质乳膏的治疗。治疗期为3周。85名患者完成了研究。在湿疹和银屑病患者中，对于所有研究参数，每日一次用药和每日两次用药之间没有统计学差异。然而，对日记卡记录的分析表明，每日两次使用丙酸倍他米松乳膏的湿疹患者症状缓解更快（P = 0.03）。每日一次使用丙酸倍他米松乳膏并联合使用润肤剂提供了一种与每日两次使用丙酸倍他米松乳膏同样有效的治疗方案。
