爱泼斯坦-巴尔病毒与人乳头瘤病毒的共同感染在人类肿瘤发生中的作用
Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis.
作者信息
Shi Ying, Peng Song-Ling, Yang Li-Fang, Chen Xue, Tao Yong-Guang, Cao Ya
机构信息
Cancer Research Institute, Central South University, Changsha, 410078, Hunan, P. R. China.
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, P. R. China.
出版信息
Chin J Cancer. 2016 Jan 22;35:16. doi: 10.1186/s40880-016-0079-1.
Abstract
Viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), are associated with 38% of all virus-associated cancers. The probability of one patient infected with these two distinct types of viruses is increasing. Here, we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.
摘要
在全球范围内，病毒感染导致约12%的癌症发生，其中绝大多数发生在发展中国家和地区。两种DNA病毒，即爱泼斯坦-巴尔病毒（EBV）和人乳头瘤病毒（HPV），与所有病毒相关癌症中的38%有关。一名患者感染这两种不同类型病毒的可能性正在增加。在此，我们总结了EBV和HPV在人类恶性肿瘤中的共同感染情况，并探讨了肿瘤发生过程中EBV和HPV共同感染的可能机制。
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