不变自然杀伤T细胞的发育。
Development of invariant natural killer T cells.
作者信息
Gapin Laurent
机构信息
Department of Immunology and Microbiology, University of Colorado Anschutz Medical campus and National Jewish Health, Aurora, CO 80045, USA.
出版信息
Curr Opin Immunol. 2016 Apr;39:68-74. doi: 10.1016/j.coi.2016.01.001. Epub 2016 Jan 21.
Abstract
Invariant natural killer T (iNKT) cells develop into functionally distinct subsets. Each subset expresses a unique combination of transcription factors that regulate cytokine gene transcription upon activation. The tissue distribution and localization within tissues also varies between subsets. Importantly, the relative abundance of the various subsets is directly responsible for altering several immunological parameters, which subsequently affect the immune response. Here, I review recent advances in our understanding of the molecular regulation of iNKT cell subset development.
摘要
不变自然杀伤T（iNKT）细胞发育为功能不同的亚群。每个亚群表达一组独特的转录因子组合，这些转录因子在激活时调节细胞因子基因转录。各亚群之间的组织分布和在组织内的定位也有所不同。重要的是，各种亚群的相对丰度直接导致若干免疫参数的改变，进而影响免疫反应。在此，我综述了我们对iNKT细胞亚群发育分子调控理解的最新进展。
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本文引用的文献
1
Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.
Immunity. 2015 Sep 15;43(3):566-78. doi: 10.1016/j.immuni.2015.06.025. Epub 2015 Sep 8.
2
Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells.
J Leukoc Biol. 2015 Nov;98(5):781-9. doi: 10.1189/jlb.1A0914-459RR. Epub 2015 Jul 17.
3
Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling.
Sci Rep. 2015 Jul 16;5:12113. doi: 10.1038/srep12113.
4
Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.
Mol Immunol. 2015 Dec;68(2 Pt A):94-7. doi: 10.1016/j.molimm.2015.06.009. Epub 2015 Jul 2.
5
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
J Exp Med. 2015 May 4;212(5):793-807. doi: 10.1084/jem.20141849. Epub 2015 Apr 20.
6
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
Nat Immunol. 2015 May;16(5):517-24. doi: 10.1038/ni.3146. Epub 2015 Apr 6.
7
The transcriptional programs of iNKT cells.
Semin Immunol. 2015 Feb;27(1):26-32. doi: 10.1016/j.smim.2015.02.005. Epub 2015 Apr 2.
8
Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.
J Exp Med. 2015 Mar 9;212(3):297-306. doi: 10.1084/jem.20141499. Epub 2015 Feb 16.
9
Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112. Epub 2014 Dec 15.
10
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Nat Immunol. 2015 Jan;16(1):85-95. doi: 10.1038/ni.3047. Epub 2014 Dec 1.
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