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免疫细胞和细胞疗法在肝细胞癌中的作用探索。

Exploration of the role of immune cells and cell therapy in hepatocellular carcinoma.

作者信息

Zhang Tao, Ren Cong, Yang Zhanyu, Zhang Ning, Tang Haowen

机构信息

Faculty of Hepato-Pancreato-Biliary Surgery, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

The Second Clinical College, Chongqing Medical University, Chongqing, China.

出版信息

Front Immunol. 2025 Apr 16;16:1569150. doi: 10.3389/fimmu.2025.1569150. eCollection 2025.

Abstract

Hepatocellular carcinoma stands as one of the foremost contributors to cancer-associated fatalities globally, and the limitations of traditional treatment methods have prompted researchers to explore new therapeutic options. Recently, cell therapy has emerged as a promising approach for HCC, showing significant potential in improving patient outcomes. This review article explores the use of cell therapy for HCC, covering different types, the mechanisms behind their effectiveness, recent advancements in clinical trials, and ongoing challenges. This article aims to provide insightful perspectives for future research and clinical applications in treating HCC by synthesizing current knowledge.

摘要

肝细胞癌是全球癌症相关死亡的主要原因之一,传统治疗方法的局限性促使研究人员探索新的治疗选择。最近,细胞疗法已成为治疗肝癌的一种有前景的方法,在改善患者预后方面显示出巨大潜力。这篇综述文章探讨了细胞疗法在肝癌治疗中的应用,涵盖了不同类型、其有效性背后的机制、临床试验的最新进展以及面临的挑战。本文旨在通过综合现有知识,为未来肝癌治疗的研究和临床应用提供有见地的观点。

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