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健康新生儿的腹主动脉血栓形成

Abdominal Aortic Thrombosis in a Healthy Neonate.

作者信息

Bogović Marko, Papeš Dino, Mitar Davorin, Smiljanić Ranko, Sršen-Medančić Suzana, Ćavar Stanko, Antabak Anko, Luetić Tomislav

机构信息

Department of Surgery, Clinical Hospital Center Zagreb, Zagreb, Croatia.

Department of Surgery, Clinical Hospital Center Zagreb, Zagreb, Croatia.

出版信息

Ann Vasc Surg. 2016 Apr;32:131.e7-9. doi: 10.1016/j.avsg.2015.10.014. Epub 2016 Jan 21.

Abstract

Abdominal aortic thrombosis is a rare entity in neonates and has mostly been associated with umbilical artery or cardiac catheterization. We present a complicated case of an otherwise healthy neonate who developed thrombosis of abdominal aorta with renal failure. Therapy with intravenous heparin was unsuccessful, and thrombolysis was contraindicated because of disseminated intravascular coagulation so we decided to perform open thrombectomy using the left retroperitoneal approach. The following day, thrombosis recurred in the same extent and despite high risk of bleeding Alteplase was eventually given, which resulted in recanalization of the aorta 6 hours later. Renal function recovered, dialysis was discontinued, and further course was uneventful. The treatment of abdominal aortic thrombosis in neonates should be considered on a case-by-case basis because the available data on the condition are limited to case report and series. If open thrombectomy is performed, retroperitoneal approach should be preferred because it allows for easy institution of peritoneal dialysis should the need arise.

摘要

腹主动脉血栓形成在新生儿中是一种罕见的病症,大多与脐动脉或心导管插入术有关。我们报告了一例复杂病例,一名原本健康的新生儿发生了腹主动脉血栓形成并伴有肾衰竭。静脉注射肝素治疗未成功,由于弥散性血管内凝血,溶栓治疗存在禁忌,因此我们决定采用左腹膜后入路进行开放性血栓切除术。次日,血栓在相同程度上复发,尽管出血风险很高,但最终还是给予了阿替普酶,6小时后主动脉再通。肾功能恢复,透析停止,后续病程平稳。新生儿腹主动脉血栓形成的治疗应根据具体情况进行考虑,因为关于该病症的现有数据仅限于病例报告和系列研究。如果进行开放性血栓切除术,应首选腹膜后入路,因为如有需要,该入路便于进行腹膜透析。

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