Noor Fauzia Ali, Hashi Asha S, Patil Rohini Kalagouda, Khainga Kennedy, Galgallo David, Kinuthia Doris, Marangu Diana, Kambuni Fred, Karuiki Nyambura, Gachara Naomi
Department of Pediatrics The Nairobi Hospital Nairobi Kenya.
Department of Radiology and Imaging The Nairobi Hospital Nairobi Kenya.
Clin Case Rep. 2025 Aug 3;13(8):e70736. doi: 10.1002/ccr3.70736. eCollection 2025 Aug.
Spontaneous abdominal aortic thrombosis in neonates due to various causes is a known entity. Hypernatremic dehydration with acute kidney injury/failure can also be one of the aetiologies. A 14- and 11-day-old term neonate born to primigravida mothers presented to two different facilities with a similar presentation of hypernatremic dehydration and acute kidney injury/failure attributed to inadequate breastfeeding causing non-catheter-related spontaneous abdominal aortic thrombosis. In both cases, initial management was supportive care, fluids and electrolyte corrections, antibiotics, and antihypertensives. Anticoagulant therapy resulted in notable improvement in renal function and general well-being of the neonates. A high index of suspicion of vascular thrombosis in neonates presenting with hypernatremic dehydration and acute renal injury/failure is key to having good clinical outcomes. Newer anticoagulant drugs like rivaroxaban can be promising in the management of neonatal aortic thrombosis.
新生儿因各种原因发生的自发性腹主动脉血栓形成是一种已知的病症。高钠血症性脱水伴急性肾损伤/肾衰竭也可能是病因之一。两名初产妇所生的足月新生儿，分别为14天和11天大，因母乳喂养不足导致非导管相关的自发性腹主动脉血栓形成，出现了类似的高钠血症性脱水和急性肾损伤/肾衰竭症状，分别就诊于两家不同的医疗机构。在这两例中，初始治疗均为支持治疗、液体和电解质纠正、抗生素及抗高血压药物治疗。抗凝治疗使新生儿的肾功能和总体健康状况有了显著改善。对于出现高钠血症性脱水和急性肾损伤/肾衰竭的新生儿，高度怀疑血管血栓形成是取得良好临床疗效的关键。新型抗凝药物如利伐沙班在新生儿主动脉血栓形成的治疗中可能很有前景。
