Massironi Sara, Zilli Alessandra, Cavalcoli Federica, Conte Dario, Peracchi Maddalena
Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy; Postgraduate School of Gastroenterology, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.
Neuropeptides. 2016 Aug;58:127-34. doi: 10.1016/j.npep.2016.01.002. Epub 2016 Jan 12.
Changes in the distribution and products of enteroendocrine cells may play a role in immune activation and regulation of gut inflammation. This review aims at critically evaluating the main enteroendocrine markers in inflammatory bowel diseases (IBD). A narrative review was performed by searching inflammatory bowel diseases and enteroendocrine biomarkers in PubMed. Relevant modifications of some enteroendocrine markers, such as Chromogranin A, and their correlation with disease activity have been reported in patients with inflammatory bowel diseases. Even if data about neuroendocrine markers are sometimes contrasting, they may be potentially useful for the diagnosis and clinical management of these patients.
肠内分泌细胞的分布和产物变化可能在肠道炎症的免疫激活和调节中发挥作用。本综述旨在批判性地评估炎症性肠病（IBD）中的主要肠内分泌标志物。通过在PubMed上搜索炎症性肠病和肠内分泌生物标志物进行了叙述性综述。在炎症性肠病患者中，已报道了一些肠内分泌标志物（如嗜铬粒蛋白A）的相关改变及其与疾病活动的相关性。即使关于神经内分泌标志物的数据有时相互矛盾，但它们可能对这些患者的诊断和临床管理具有潜在的用途。
