Hernández Theresa D, Brenner Lisa A, Walter Kristen H, Bormann Jill E, Johansson Birgitta
Department of Psychology and Neuroscience, University of Colorado at Boulder, United States; Center for Neuroscience, University of Colorado at Boulder, United States; Department of Veterans Affairs, Rocky Mountain Mental Illness Research, Education and Clinical Center (MIRECC), United States.
Department of Veterans Affairs, Rocky Mountain Mental Illness Research, Education and Clinical Center (MIRECC), United States; Department of Psychiatry, University of Colorado Anschutz Medical Campus, United States; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, United States; Department of Neurology, University of Colorado Anschutz Medical Campus, United States.
Brain Res. 2016 Jun 1;1640(Pt A):139-151. doi: 10.1016/j.brainres.2016.01.025. Epub 2016 Jan 21.
Traumatic brain injury (TBI) is highly prevalent and occurs in a variety of populations. Because of the complexity of its sequelae, treatment strategies pose a challenge. Given this complexity, TBI provides a unique target of opportunity for complementary and alternative medicine (CAM) treatments. The present review describes and discusses current opportunitites and challenges associated with CAM research and clinical applications in civilian, veteran and military service populations. In addition to a brief overview of CAM, the translational capacity from basic to clinical research to clinical practice will be described. Finally, a systematic approach to developing an adoptable evidence base, with proof of effectiveness based on the literature will be discussed. Inherent in this discussion will be the methodological and ethical challenges associated with CAM research in those with TBI and associated comorbidities, specifically in terms of how these challenges relate to practice and policy issues, implementation and dissemination. This article is part of a Special Issue entitled SI:Brain injury and recovery.
创伤性脑损伤（TBI）非常普遍，在各类人群中均有发生。由于其后遗症的复杂性，治疗策略颇具挑战。鉴于这种复杂性，TBI为补充和替代医学（CAM）治疗提供了独特的机会靶点。本综述描述并讨论了与CAM在平民、退伍军人和军事服役人群中的研究及临床应用相关的当前机遇与挑战。除了对CAM进行简要概述外，还将描述从基础研究到临床研究再到临床实践的转化能力。最后，将讨论一种基于文献证据开发可采用的证据基础的系统方法。此讨论中固有的将是与TBI及相关合并症患者的CAM研究相关的方法学和伦理挑战，特别是这些挑战如何与实践和政策问题、实施与传播相关联。本文是名为“SI：脑损伤与恢复”的特刊的一部分。
