Patel Kaushal, Sun Dong
Department of Neurosurgery, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States.
Department of Neurosurgery, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States.
Brain Res. 2016 Jun 1;1640(Pt A):104-113. doi: 10.1016/j.brainres.2016.01.055. Epub 2016 Feb 8.
Traumatic brain injury (TBI) affects over 1.7 million people in the United States alone and poses many clinical challenges due to the variability of the injuries and complexity of biochemical mechanisms involved. Thus far, there is still no effective therapy for TBI. Failure of preventative therapeutic strategies has led studies focusing on regenerative approaches. Recent studies have shown evidence that mature brains harbors multipotent neural stem cells capable of becoming mature neurons in the neurogenic regions. Following brain insults including TBI, the injured brain has increased level of neurogenic response in the subventricular zone and dentate gyrus of the hippocampus and this endogenous response is associated with cognitive function following injury. In this review, we highlight recent development and strategies aimed at targeting this endogenous cell response to enhance post-TBI functional recovery. This article is part of a Special Issue entitled SI:Brain injury and recovery.
仅在美国，创伤性脑损伤（TBI）就影响着超过170万人，由于损伤的变异性和所涉及生化机制的复杂性，它带来了许多临床挑战。到目前为止，仍没有针对TBI的有效治疗方法。预防性治疗策略的失败促使研究转向再生方法。最近的研究表明，成熟大脑在神经发生区域含有能够分化为成熟神经元的多能神经干细胞。在包括TBI在内的脑损伤后，受损大脑在脑室下区和海马齿状回的神经发生反应水平升高，这种内源性反应与损伤后的认知功能相关。在这篇综述中，我们重点介绍了旨在针对这种内源性细胞反应以促进TBI后功能恢复的最新进展和策略。本文是名为“SI：脑损伤与恢复”特刊的一部分。
