多不饱和溶血磷脂酸作为一种潜在的哮喘生物标志物。
Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.
作者信息
Ackerman Steven J, Park Gye Young, Christman John W, Nyenhuis Sharmilee, Berdyshev Evgeny, Natarajan Viswanathan
机构信息
Department of Biochemistry & Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
出版信息
Biomark Med. 2016;10(2):123-35. doi: 10.2217/bmm.15.93. Epub 2016 Jan 14.
Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid from asthmatic lung, and are strongly induced following subsegmental bronchoprovocation with allergen in subjects with allergic asthma. Polyunsaturated molecular species of LPA (C22:5 and C22:6) are selectively synthesized in the airways of asthma subjects following allergen challenge and in mouse models of allergic airway inflammation, having been identified and quantified by LC/MS/MS lipidomics. This review discusses current knowledge of LPA production in asthmatic lung and the potential utility of polyunsaturated LPA molecular species as novel biomarkers in bronchoalveolar lavage fluid and exhaled breath condensate of asthma subjects.
溶血磷脂酸（LPA）是生物体液和组织中的一种脂质介质，主要由自分泌运动因子产生，该因子将溶血磷脂酰胆碱水解为LPA和胆碱。哮喘患者肺支气管肺泡灌洗液中的总LPA水平升高，在过敏性哮喘患者中，过敏原进行亚节段支气管激发后，LPA水平会强烈升高。LPA的多不饱和分子种类（C22:5和C22:6）在过敏原激发后的哮喘患者气道以及过敏性气道炎症小鼠模型中被选择性合成，已通过液相色谱/串联质谱脂质组学进行了鉴定和定量。本综述讨论了目前关于哮喘患者肺中LPA产生的知识，以及多不饱和LPA分子种类作为哮喘患者支气管肺泡灌洗液和呼出气冷凝物中新的生物标志物的潜在用途。
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