自分泌酶/溶血磷脂酸在免疫调节和哮喘中的作用。
The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma.
机构信息
Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May;1865(5):158641. doi: 10.1016/j.bbalip.2020.158641. Epub 2020 Jan 29.
Abstract
Lysophosphatidic acid (LPA) species are present in almost all organ systems and play diverse roles through its receptors. Asthma is an airway disease characterized by chronic allergic inflammation where various innate and adaptive immune cells participate in establishing Th2 immune response. Here, we will review the contribution of LPA and its receptors to the functions of immune cells that play a key role in establishing allergic airway inflammation and aggravation of allergic asthma.
摘要
溶血磷脂酸（LPA）种类存在于几乎所有的器官系统中，并通过其受体发挥多种作用。哮喘是一种气道疾病，其特征为慢性过敏性炎症，其中各种先天和适应性免疫细胞参与建立 Th2 免疫反应。在这里，我们将回顾 LPA 及其受体对在建立过敏性气道炎症和加重过敏性哮喘中起关键作用的免疫细胞功能的贡献。
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