Wu Chuan-Chang, Hung Shih-Han, Lin Herng-Ching, Lee Cha-Ze, Lee Hsin-Chien, Chung Shiu-Dong
a School of Health Care Administration , Taipei Medical University , Taipei , Taiwan ;
b Department of Plastic Surgery , Taipei City Hospital , Taipei , Taiwan ;
Acta Otolaryngol. 2016;136(5):497-500. doi: 10.3109/00016489.2015.1129068. Epub 2016 Jan 25.
This study demonstrates an association between sialolithiasis and nephrolithiasis. The results call for more awareness of this association among physicians and patients with nephrolithiasis.
Very few empirical studies have been conducted to explore the potential association between sialolithiasis and nephrolithiasis. As such, the association between sialolithiasis and nephrolithiasis still remains unclear. This study aimed to explore the possible association between sialolithiasis and nephrolithiasis using a population-based dataset.
Using data from the Taiwan Longitudinal Health Insurance Database 2005, this case-control study identified 966 patients with sialolithiasis as cases and 2898 sex- and age-matched subjects without sialolithiasis as controls. Conditional logistic regressions were conducted to examine the association of sialolithiasis with previously diagnosed nephrolithiasis.
Out of 3864 sampled patients, 165 (4.27%) had prior nephrolithiasis. Using Chi-square test, it was found that there was a significant difference in the prevalence of prior nephrolithiasis between the cases and controls (10.25% vs 2.28%, p < 0.001). Moreover, by conditional logistic regression analysis, the odds ratio of prior nephrolithiasis for cases was 4.74 (95% CI = 3.41-6.58, p < 0.001) when compared to controls after adjusting for monthly income, geographic location, urbanization level of residence, diabetes, hypertension, heart failure, chronic renal disease, and tobacco use.
本研究表明涎石病与肾结石之间存在关联。研究结果呼吁肾结石患者及其医生提高对这种关联的认识。
很少有实证研究探讨涎石病与肾结石之间的潜在关联。因此，涎石病与肾结石之间的关联仍不明确。本研究旨在使用基于人群的数据集探讨涎石病与肾结石之间可能存在的关联。
利用2005年台湾纵向健康保险数据库的数据，这项病例对照研究确定了966例涎石病患者作为病例组，以及2898例年龄和性别匹配的无涎石病受试者作为对照组。进行条件逻辑回归分析以检验涎石病与先前诊断的肾结石之间的关联。
在3864名抽样患者中，165名（4.27%）曾患肾结石。通过卡方检验发现，病例组和对照组中既往肾结石患病率存在显著差异（10.25%对2.28%，p<0.001）。此外，通过条件逻辑回归分析，在调整月收入、地理位置、居住城市化水平、糖尿病、高血压、心力衰竭、慢性肾病和吸烟情况后，病例组既往患肾结石的比值比为4.74（95%CI=3.41-6.58，p<0.001），与对照组相比。
