Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
Center for Primary Health Care Research, Lund University, 205 02, Malmö, Sweden.
Sci Rep. 2018 Feb 15;8(1):3083. doi: 10.1038/s41598-018-21410-0.
Urolithiasis (UL, urinary tract stone disease) has been reported to increase subsequent cancers in the urinary tract. Recently, we showed data that surveillance bias may be an important confounder in the reported associations. In the present approach we want to address the question of possible cancer risk posed by UL mechanistically. Both UL and cancer have strong genetic components and we hypothesize that familial association between UL and cancer may be plausible. We thus assess familial risks between UL and cancer, hoping to find an explanation why UL may pose a risk of cancer. UL patients were identified from hospital inpatient and outpatient records and they were organized in families based on the Multigeneration Register into which also national cancer data were linked. Standardized incidence ratios were calculated for cancer in the offspring generation when parents were diagnosed with UL, and conversely for UL when parents were diagnosed with cancer. Familial risks between UL and cancer were generally small and inconsistent providing no convincing support of genetic sharing between UL and cancer. However, bladder UL was associated weakly with prostate cancer, and ureter and bladder UL were associated with salivary gland cancer. Potential mechanisms for these findings are proposed.
尿路结石（UL，尿路结石病）已被报道会增加后续的尿路癌症。最近，我们的数据表明，监测偏差可能是报告中关联的一个重要混杂因素。在本研究中，我们希望从机制上探讨 UL 引起癌症风险的可能性。UL 和癌症都有很强的遗传成分，我们假设 UL 和癌症之间的家族关联性是合理的。因此，我们评估了 UL 和癌症之间的家族风险，希望找到为什么 UL 可能会增加癌症风险的解释。通过医院住院和门诊记录确定 UL 患者，并根据多代登记系统将其组织成家庭，该登记系统还与国家癌症数据相关联。当父母被诊断患有 UL 时，计算子女代患癌症的标准化发病比，反之亦然，当父母被诊断患有癌症时，计算 UL 的标准化发病比。UL 和癌症之间的家族风险通常较小且不一致，不能为 UL 和癌症之间的遗传共享提供令人信服的支持。然而，膀胱 UL 与前列腺癌弱相关，输尿管和膀胱 UL 与唾液腺癌相关。对这些发现的潜在机制进行了探讨。
