Mehregan D A, Umbert I J, Peters M S
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
J Am Acad Dermatol. 1989 Nov;21(5 Pt 2):1107-12. doi: 10.1016/s0190-9622(89)70307-8.
The association of bullous pemphigoid with other immune-mediated diseases has been described; however, coexistence with other bullous dermatoses is unusual. We describe a patient with longstanding localized bullous pemphigoid and the recent finding of a Hailey-Hailey-like histologic pattern in a biopsy specimen obtained at a site of active pemphigoid involvement, as confirmed by immunofluorescence studies. Although this case suggests the possibility of coexistence of two bullous diseases, the Hailey-Hailey-like pattern more likely represents an incidental microscopic finding or a solitary acantholytic lesion.
大疱性类天疱疮与其他免疫介导疾病的关联已有描述；然而，与其他大疱性皮肤病共存并不常见。我们报告一名长期患有局限性大疱性类天疱疮的患者，在活动性类天疱疮累及部位获取的活检标本中最近发现了类似黑利-黑利病的组织学模式，免疫荧光研究证实了这一点。尽管该病例提示两种大疱性疾病共存的可能性，但类似黑利-黑利病的模式更可能是偶然的显微镜下发现或孤立的棘层松解性病变。
