Al-Dughaishi Tamima, Al Harrasi Yusra, Al-Duhli Maymoona, Al-Rubkhi Ikhlass, Al-Riyami Nihal, Al Riyami Arwa, Pathare Anil V, Gowri Vaidyanathan
Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Muscat, Oman.
School of Medicine, Sultan Qaboos University, Muscat, Oman.
Oman Med J. 2016 Jan;31(1):77-80. doi: 10.5001/omj.2016.15.
The detection of maternal alloimmunization against red cell antigens is vital in the management of hemolytic disease of the fetus and newborn. We sought to measure the presence of allosensitization to Rhesus D (RhD) antibodies in antenatal women attending a tertiary care hospital and assess the fetal outcome in sensitized women.
We conducted a retrospective review of pregnant Omani women who registered at the Sultan Qaboos University Hospital between June 2011 and June 2013. Pregnant women were tested for ABO blood type and were screened for RhD antigen and antibodies at their first antenatal clinic visit. In women who tested positive for the RhD antibodies, an antibody titer was performed to evaluate the severity of their case.
Data was available on 1,251 pregnant women who were managed and delivered at Sultan Qaboos University Hospital. The prevalence of RhD negative pregnant women was 7.3%. Blood group O was the most common followed by A, B, and AB. The rate of RhD negative alloimmunization was 10%, and anti-D was the most common antibody detected. There were no stillbirths or neonatal deaths. Postnatal transfusion was necessary for only one baby.
The prevalence of RhD negativity was comparable to other Asian countries. Previous RhD alloimmunization and history of miscarriages were the most common maternal medical history.
检测母体针对红细胞抗原的同种免疫在胎儿和新生儿溶血病的管理中至关重要。我们试图测量在一家三级护理医院就诊的产前女性中对恒河猴D（RhD）抗体的同种致敏情况，并评估致敏女性的胎儿结局。
我们对2011年6月至2013年6月在苏丹卡布斯大学医院登记的阿曼孕妇进行了回顾性研究。孕妇在首次产前门诊就诊时检测ABO血型，并筛查RhD抗原和抗体。对RhD抗体检测呈阳性的女性，进行抗体滴度检测以评估其病情严重程度。
有1251名在苏丹卡布斯大学医院接受管理和分娩的孕妇的数据。RhD阴性孕妇的患病率为7.3%。O型血是最常见的，其次是A型、B型和AB型。RhD阴性同种免疫的发生率为10%，检测到的最常见抗体是抗-D。没有死产或新生儿死亡。只有一名婴儿需要产后输血。
RhD阴性的患病率与其他亚洲国家相当。既往RhD同种免疫和流产史是最常见的母亲病史。
