Bondagji Nabeel S
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Princes Al-Johra Center of Excellence for Genetic Disease, King Abdul-Aziz University, College of Medicine, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia.
Saudi Med J. 2011 Oct;32(10):1039-45.
To determine the distribution of ABO blood group and rhesus (RH) factor among pregnant women, to estimate the prevalence of Rh alloimmunization, and report the perinatal outcome of all cases of Rh alloimmunization at King Abdul-Aziz University Hospital (KAUH).
This is a retrospective study of pregnant women attending the antenatal clinics in KAUH, Jeddah, Saudi Arabia between January 2004 and December 2009. Records of patient diagnosed as Rh negative blood group were reviewed for the presence of antibodies, antibodies titer, and progress in the level of antibodies. Maternal and neonatal outcomes were reported.
Twenty-four thousand and five pregnant women were included in this study. The most common blood group was O followed by A, B and AB positive. Rhesus negativity blood group was reported in 7.5%. Four hundred and twenty-four cases were reported as Rh antibody positive with a prevalence of alloimmunization of 1.8% in the studied population, and 23.6% among Rh negative women. The perinatal mortality rate was 250 per 1000 in alloimmunized women compared to 17 per 1000 in the study population.
Blood group O positive is the most prevalent blood group among pregnant women attending our antenatal clinics and the prevalence of Rh negativity was 7.5%. The prevalence of Rh alloimmunization in the present study was 10-folds higher than that reported in the developed countries. Rhesus alloimmunization represent an avoidable direct cause for perinatal morbidity and mortality in our population.
确定孕妇中ABO血型和恒河猴（RH）因子的分布，估计Rh同种免疫的患病率，并报告阿卜杜勒-阿齐兹国王大学医院（KAUH）所有Rh同种免疫病例的围产期结局。
这是一项对2004年1月至2009年12月期间在沙特阿拉伯吉达KAUH产前诊所就诊的孕妇进行的回顾性研究。对诊断为Rh阴性血型的患者记录进行审查，以检查抗体的存在、抗体滴度以及抗体水平的变化情况。报告母婴结局。
本研究纳入了24005名孕妇。最常见的血型是O型，其次是A、B和AB阳性。Rh阴性血型的报告率为7.5%。有424例报告为Rh抗体阳性，在所研究人群中同种免疫的患病率为1.8%，在Rh阴性女性中为23.6%。Rh同种免疫女性的围产期死亡率为每1000例中有250例，而研究人群中为每1000例中有17例。
在我们产前诊所就诊的孕妇中，O型阳性血型最为普遍，Rh阴性的患病率为7.5%。本研究中Rh同种免疫的患病率比发达国家报告的高出10倍。Rh同种免疫是我们人群中围产期发病和死亡的一个可避免的直接原因。
