关节软骨小泡与钙晶体沉积疾病
Articular cartilage vesicles and calcium crystal deposition diseases.
作者信息
Rosenthal Ann K
机构信息
aDivision of Rheumatology, Department of Medicine, Medical College of Wisconsin bZablocki VA Medical Center, Milwaukee, Wisconsin, USA.
出版信息
Curr Opin Rheumatol. 2016 Mar;28(2):127-32. doi: 10.1097/BOR.0000000000000244.
PURPOSE OF REVIEW
Articular cartilage vesicles (ACVs) are small extracellular vesicles that serve as foci of pathologic calcium crystal deposition in articular cartilage matrix. In this review, I have summarized the role of ACVs in calcium crystal formation and discuss recent findings that impact our understanding of the content, behavior, and origin of ACVs in healthy and diseased joints. The burgeoning interest in extracellular vesicles in other fields renders this a timely and relevant topic.
RECENT FINDINGS
I have highlighted recent studies demonstrating that some ACVs originate in the autophagic pathway in healthy articular chondrocytes. I have reviewed accumulating evidence that nonmineralizing functions of ACVs contribute to osteoarthritis. I have also discussed new work supporting a role for extracellular vesicles in interleukin-1β-induced mineralization and in mediating the catabolic effects of synovial inflammation in osteoarthritis.
SUMMARY
We are making slow and steady progress in understanding the origin and function of ACVs and other relevant extracellular vesicles in arthritis. Further work in this interesting area is warranted.
综述目的
关节软骨小泡（ACV）是一种小的细胞外囊泡，是关节软骨基质中病理性钙晶体沉积的焦点。在本综述中，我总结了ACV在钙晶体形成中的作用，并讨论了近期的研究结果，这些结果影响了我们对健康和患病关节中ACV的内容、行为及起源的理解。其他领域对细胞外囊泡的兴趣日益浓厚，使得这成为一个及时且相关的话题。
近期研究发现
我重点介绍了近期的研究，这些研究表明一些ACV起源于健康关节软骨细胞的自噬途径。我回顾了越来越多的证据表明ACV的非矿化功能与骨关节炎有关。我还讨论了新的研究工作，这些工作支持细胞外囊泡在白细胞介素-1β诱导的矿化以及介导骨关节炎滑膜炎症的分解代谢作用中发挥作用。
总结
我们在理解ACV及其他相关细胞外囊泡在关节炎中的起源和功能方面正在稳步取得缓慢进展。在这个有趣的领域有必要开展进一步的工作。
Zotero 插件