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Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer's Disease.

作者信息

Pachima Yanina Ivashko, Zhou Liu-yao, Lei Peng, Gozes Illana

机构信息

Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978, Israel.

Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan, 610041, China.

出版信息

J Mol Neurosci. 2016 Feb;58(2):145-52. doi: 10.1007/s12031-016-0715-x.

DOI:10.1007/s12031-016-0715-x
PMID:26816082
Abstract
摘要

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2
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Science. 2007 Jun 8;316(5830):1416-7. doi: 10.1126/science.316.5830.1416.
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Modification of tau to an Alzheimer's type protein interferes with its interaction with microtubules.tau蛋白向阿尔茨海默病型蛋白的转变会干扰其与微管的相互作用。
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Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects.Tau作为微管相关蛋白的作用：结构与功能方面
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Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease.阿尔茨海默病中 Tau 磷酸化的表观遗传调控。

本文引用的文献

1
Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory.微管功能的性差异：新型鼻内微管靶向 SKIP 可使轴突运输正常化并增强记忆。
Mol Psychiatry. 2016 Oct;21(10):1467-76. doi: 10.1038/mp.2015.208. Epub 2016 Jan 19.
2
Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.血源性活性依赖神经保护蛋白（ADNP）与病前智力、临床分期及阿尔茨海默病生物标志物相关。
J Alzheimers Dis. 2016;50(1):249-60. doi: 10.3233/JAD-150799.
3
Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau.
Neural Plast. 2019 Apr 10;2019:6856327. doi: 10.1155/2019/6856327. eCollection 2019.
4
Simulating tubulin-associated unit transport in an axon: using bootstrapping for estimating confidence intervals of best-fit parameter values obtained from indirect experimental data.模拟轴突中微管相关单元的运输：使用自抽样法估计从间接实验数据获得的最佳拟合参数值的置信区间。
Proc Math Phys Eng Sci. 2017 May;473(2201):20170045. doi: 10.1098/rspa.2017.0045. Epub 2017 May 3.
5
The Future for Dementia Research: a Perspective from the Journal of Molecular Neuroscience.痴呆症研究的未来：来自《分子神经科学杂志》的视角
J Mol Neurosci. 2016 Nov;60(3):410-411. doi: 10.1007/s12031-016-0841-5.
6
Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.α-突触核蛋白与tau蛋白之间的相互作用：对神经退行性疾病的影响。
J Mol Neurosci. 2016 Nov;60(3):298-304. doi: 10.1007/s12031-016-0829-1. Epub 2016 Sep 15.
海马淀粉样前体蛋白和铁的持续升高是β-淀粉样蛋白毒性的特征，并由tau蛋白介导。
Neurotherapeutics. 2015 Oct;12(4):862-73. doi: 10.1007/s13311-015-0378-2.
4
Tau phosphorylation at serine 396 residue is required for hippocampal LTD.海马体长时程抑制（LTD）需要tau蛋白在丝氨酸396残基处发生磷酸化。
J Neurosci. 2015 Mar 25;35(12):4804-12. doi: 10.1523/JNEUROSCI.2842-14.2015.
5
Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals.认知正常个体中阿尔茨海默病的营养模式和脑生物标志物
J Nutr Health Aging. 2015 Apr;19(4):413-23. doi: 10.1007/s12603-014-0534-0.
6
The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins.活性依赖性神经保护蛋白（ADNP）的 NAP 基序通过微管末端结合蛋白调节树突棘。
Mol Psychiatry. 2014 Oct;19(10):1115-24. doi: 10.1038/mp.2014.97. Epub 2014 Sep 2.
7
Motor and cognitive deficits in aged tau knockout mice in two background strains.两种背景品系的老年tau基因敲除小鼠的运动和认知缺陷
Mol Neurodegener. 2014 Aug 14;9:29. doi: 10.1186/1750-1326-9-29.
8
Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.锌结合直接调节tau毒性，与tau过度磷酸化无关。
Cell Rep. 2014 Aug 7;8(3):831-42. doi: 10.1016/j.celrep.2014.06.047. Epub 2014 Jul 24.
9
Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion.纯合tau缺失小鼠的认知与海马突触可塑性
Neurobiol Aging. 2014 Nov;35(11):2474-2478. doi: 10.1016/j.neurobiolaging.2014.05.005. Epub 2014 May 10.
10
Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.Tau缺失导致果蝇光感受器发育缺陷和神经元进行性退化。
Dev Neurobiol. 2014 Dec;74(12):1210-25. doi: 10.1002/dneu.22199. Epub 2014 Jun 18.