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利用碱基乌拉尔与抗肿瘤药物甲氨蝶呤的氢键相互作用，设计具有超高载药效率和 pH 响应性药物释放的药物载体。

Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release.

机构信息

Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, China.

出版信息

Regen Biomater. 2014 Nov;1(1):27-35. doi: 10.1093/rb/rbu010. Epub 2014 Oct 20.

DOI:10.1093/rb/rbu010
PMID:26816622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4669001/
Abstract

A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.

摘要

一种新型含乌拉尔烷（U）线性超支化单甲氧基聚乙二醇-超支化聚甘油接枝乌拉尔烷（mPEG-HPG-g-U）纳米颗粒（NP）被制备为用于抗肿瘤药物甲氨蝶呤（MTX）的载体。由于 U 与 MTX 之间的氢键相互作用和疏水相互作用，该 NP 表现出高达 40%的高载药效率，明显高于基于不含 U 的共聚物的传统 NP（<15%）。此外，载有 MTX 的 mPEG-HPG-g-U NPs 还表现出酸加速的药物释放行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/66d116cc02e3/rbu010f8p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/4f1a5866991f/rbu010f9p.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/80e907e6ea9a/rbu010f2p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/1a6e7e696002/rbu010f3p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/3be09afde77a/rbu010f4p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/b95e39282c06/rbu010f5p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/8d99027a9c7e/rbu010f6p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/69fc7ea7b6a0/rbu010f7p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/66d116cc02e3/rbu010f8p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/4f1a5866991f/rbu010f9p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/775215fea7d7/rbu010f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/80e907e6ea9a/rbu010f2p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/1a6e7e696002/rbu010f3p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/3be09afde77a/rbu010f4p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/b95e39282c06/rbu010f5p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/8d99027a9c7e/rbu010f6p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/69fc7ea7b6a0/rbu010f7p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/4669001/66d116cc02e3/rbu010f8p.jpg

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