College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China; State Key Laboratory of Mining Disaster Prevention and Control Co-Founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China.
Regen Biomater. 2016 Mar;3(1):49-56. doi: 10.1093/rb/rbv028. Epub 2016 Jan 6.
In vivo degradation predication faces a huge challenge via in vitro corrosion test due to the difficulty for mimicking the complicated microenvironment with various influencing factors. A thin electrolyte layer (TEL) cell for in vitro corrosion of pure magnesium and AZ91 alloy was presented to stimulate the in vivo corrosion in the micro-environment built by the interface of the implant and its neighboring tissue. The results demonstrated that the in vivo corrosion of pure Mg and the AZ91 alloy was suppressed under TEL condition. The AZ91 alloy was more sensitive than pure Mg to the inhibition of corrosion under a TEL thickness of less than 200 µm. The TEL thickness limited the distribution of current, and thus localized corrosion was more preferred to occur under TEL condition than in bulk solution. The TEL cell might be an appropriate approach to simulating the in vivo degradation of magnesium and its alloys.
体内降解预测通过体外腐蚀试验面临巨大挑战，因为难以模拟具有各种影响因素的复杂微环境。提出了一种用于纯镁和 AZ91 合金体外腐蚀的薄电解质层（TEL）电池，以刺激植入物与其邻近组织界面所构成的微环境中的体内腐蚀。结果表明，在 TEL 条件下，纯镁和 AZ91 合金的体内腐蚀受到抑制。在 TEL 厚度小于 200 µm 的情况下，AZ91 合金比纯镁对腐蚀抑制更为敏感。TEL 厚度限制了电流的分布，因此在 TEL 条件下比在本体溶液中更倾向于发生局部腐蚀。TEL 电池可能是模拟镁及其合金体内降解的一种合适方法。
