Biomaterials and Engineering Materials (BEM) Laboratory, College of Science, Technology and Engineering, James Cook University, Townsville, Queensland 4811, Australia; Biometals Group, International Centre for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan.
Biometals Group, International Centre for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan.
Colloids Surf B Biointerfaces. 2015 Feb 1;126:603-6. doi: 10.1016/j.colsurfb.2015.01.015. Epub 2015 Jan 17.
In this study, the influence of living cells (L929) on the in vitro degradation behaviour of a magnesium-calcium alloy was investigated using an electrochemical technique in the Eagle's minimum essential medium (EMEM) with 10% foetal bovine serum (FBS) under 5% CO2 atmosphere. The degradation of the alloy increased significantly in the medium containing the cells as compared to that without cells. Post-degradation analysis revealed localized degradation in the vicinity of the cells. It is suggested that the cell metabolic activity has induced local pH drop and as a result increased the alloy degradation.
在这项研究中，使用电化学技术在含有 10%胎牛血清（FBS）的 Eagle's 最小必需培养基（EMEM）中、在 5% CO2 气氛下，研究了活细胞（L929）对镁钙合金体外降解行为的影响。与不含细胞的培养基相比，细胞存在时合金的降解显著增加。降解后分析表明，细胞附近存在局部降解。研究表明，细胞代谢活性导致局部 pH 值下降，从而加速了合金的降解。
