男性雄激素缺乏与代谢综合征
Androgen deficiency and metabolic syndrome in men.
作者信息
Winter Ashley G, Zhao Fujun, Lee Richard K
机构信息
1 James Buchanan Brady Foundation, Department of Urology, Weill Medical College of Cornell University, New York, NY 10065, USA ; 2 Department of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 20080, China.
出版信息
Transl Androl Urol. 2014 Mar;3(1):50-8. doi: 10.3978/j.issn.2223-4683.2014.01.04.
Metabolic syndrome (MetS) is a growing health concern worldwide. Initially a point of interest in cardiovascular events, the cluster of HTN, obesity, dyslipidemia, and insulin resistance known as MetS has become associated with a variety of other disease processes, including androgen deficiency and late-onset hypogonadism (LOH). Men with MetS are at a higher risk of developing androgen deficiency, and routine screening of testosterone (T) is advised in this population. The pathophysiology of androgen deficiency in MetS is multifactorial, and consists of inflammatory, enzymatic, and endocrine derangements. Many options for the concomitant treatment of both disorders exist. Direct treatment of MetS, whether by diet, exercise, or surgery, may improve T levels. Conversely, testosterone replacement therapy (TRT) has been shown to improve MetS parameters in multiple randomized controlled trials (RTCs).
代谢综合征（MetS）是全球范围内日益受到关注的健康问题。最初它是心血管事件的一个关注点，被称为MetS的高血压、肥胖、血脂异常和胰岛素抵抗的组合已与包括雄激素缺乏和迟发性性腺功能减退（LOH）在内的多种其他疾病过程相关联。患有MetS的男性发生雄激素缺乏的风险更高，因此建议对该人群进行常规睾酮（T）筛查。MetS中雄激素缺乏的病理生理学是多因素的，包括炎症、酶和内分泌紊乱。同时治疗这两种疾病有多种选择。直接治疗MetS，无论是通过饮食、运动还是手术，都可能改善T水平。相反，在多项随机对照试验（RTC）中，睾酮替代疗法（TRT）已被证明可改善MetS参数。
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