Damphousse Kristen E, Mowls Dana S, Beebe Laura A
J Okla State Med Assoc. 2015 Nov;108(11):488-91.
As the 8th most frequently diagnosed cancers among U.S. males, cancers of the oral cavity and pharynx are a significant component of the cancer burden among U.S. males. Avoidance of tobacco products is critical for the prevention of oral cavity and pharynx cancers. The objective of this brief report was to describe state-specific incidence rates of oral cavity and pharynx cancers and to examine the correlation between state-specific prevalences of tobacco use and oral cavity and pharynx cancer incidence rates among U.S. adult males.
Secondary surveillance data were used to conduct this ecological analysis. Incidence rates of oral cavity and pharynx cancers during 2009 through 2011 among males were obtained from the Centers for Disease Control and Prevention (CDC) WONDER system. Prevalences of cigarette smoking and smokeless tobacco use during 1995 and 1996 among males were obtained from the CDC STATE System. Relations were examined by calculating Pearson correlation coefficients and by performing linear regression analysis. Statistical significance was considered at alpha < 0.05.
Current cigarette smoking prevalence was significantly correlated (r = 0.57; r2 = 0.33; p-value = < .0001) with the incidence rate of oral cavity and pharynx cancer; while there was a non-statistically significant correlation (r = 0.22; r2 = 0.05; p-value = 0.1147) between smokeless tobacco use and oral cavity and pharynx cancer. A 1% increase in the prevalence of current cigarette smoking was estimated to increase the incidence rate of oral cavity and pharynx cancer by 0.52 per 100,000 males. Although non-statistically significant, a 1% increase in the prevalence of smokeless tobacco use was estimated to increase the incidence rate of oral cavity and pharynx cancer by 0.18 per 100,000 males.
Among U.S. males, a statistically significant positive correlation was observed between cigarette smoking and oral cancer, but not between smokeless tobacco use and oral cancer. Moreover, current cigarette smoking was estimated to predict one-third of the total variability in oral cancer. These findings contribute to the body of literature and provide further evidence that cigarette smoking is an important behavioral risk factor for oral cavity and pharynx cancer among U.S. males.
口腔和咽癌是美国男性中第八大最常诊断出的癌症，是美国男性癌症负担的重要组成部分。避免使用烟草制品对于预防口腔和咽癌至关重要。本简要报告的目的是描述各州口腔和咽癌的发病率，并研究美国成年男性中各州烟草使用流行率与口腔和咽癌发病率之间的相关性。
使用二次监测数据进行这项生态分析。2009年至2011年男性口腔和咽癌的发病率来自疾病控制和预防中心（CDC）的WONDER系统。1995年和1996年男性吸烟和无烟烟草使用的流行率来自CDC的STATE系统。通过计算Pearson相关系数和进行线性回归分析来检验关系。当α<0.05时认为具有统计学意义。
当前吸烟流行率与口腔和咽癌发病率显著相关（r = 0.57；r2 = 0.33；p值 = <.0001）；而无烟烟草使用与口腔和咽癌之间存在非统计学显著相关性（r = 0.22；r2 = 0.05；p值 = 0.1147）。据估计，当前吸烟流行率每增加1%，每10万名男性中口腔和咽癌的发病率将增加0.52。虽然无统计学意义，但无烟烟草使用流行率每增加1%，据估计每10万名男性中口腔和咽癌的发病率将增加0.18。
在美国男性中，观察到吸烟与口腔癌之间存在统计学显著的正相关，但无烟烟草使用与口腔癌之间不存在这种相关性。此外，据估计当前吸烟可预测口腔癌总变异性的三分之一。这些发现丰富了文献，并进一步证明吸烟是美国男性口腔和咽癌的重要行为危险因素。
