Artuğ N Tuğrul, Goker Imran, Bolat Bülent, Osman Onur, Kocasoy Orhan Elif, Baslo M Baris
Electrical and Electronics Engineering, Istanbul Arel University, Tepekent, Buyukcekmece, Istanbul, Turkey.
Biomedical Engineering, Istanbul Arel University, Tepekent, Buyukcekmece, Istanbul, Turkey.
Comput Methods Programs Biomed. 2016 Jun;129:172-85. doi: 10.1016/j.cmpb.2016.01.003. Epub 2016 Jan 14.
Motor unit action potential (MUAP), which consists of individual muscle fiber action potentials (MFAPs), represents the electrical activity of the motor unit. The values of the MUAP features are changed by denervation and reinnervation in neurogenic involvement as well as muscle fiber loss with increased diameter variability in myopathic diseases. The present study is designed to investigate how increased muscle fiber diameter variability affects MUAP parameters in simulated motor units. In order to detect this variation, simulated MUAPs were calculated both at the innervation zone where the MFAPs are more synchronized, and near the tendon, where they show increased temporal dispersion. Reinnervation in neurogenic state increases MUAP amplitude for the recordings at both the innervation zone and near the tendon. However, MUAP duration and the number of peaks significantly increased in a case of myopathy for recordings near the tendon. Furthermore, of the new features, "number of peaks×spike duration" was found as the strongest indicator of MFAP dispersion in myopathy. MUAPs were also recorded from healthy participants in order to investigate the biological counterpart of the simulation data. MUAPs which were recorded near to tendon revealed significantly prolonged duration and decreased amplitude. Although the number of peaks was increased by moving the needle near to tendon, this was not significant.
运动单位动作电位（MUAP）由单个肌纤维动作电位（MFAP）组成，代表运动单位的电活动。在神经源性病变中，去神经和再神经支配会改变MUAP特征值，在肌病中，肌纤维丢失且直径变异性增加也会改变MUAP特征值。本研究旨在探讨肌纤维直径变异性增加如何影响模拟运动单位中的MUAP参数。为了检测这种变化，在MFAP同步性更高的神经支配区和肌腱附近（此处MFAP的时间离散增加）计算模拟MUAP。神经源性状态下的再神经支配会增加神经支配区和肌腱附近记录的MUAP波幅。然而，在肌腱附近记录的肌病病例中，MUAP时限和峰数显著增加。此外，在新特征中，“峰数×棘波时限”被发现是肌病中MFAP离散的最强指标。还记录了健康参与者的MUAP，以研究模拟数据的生物学对应情况。在肌腱附近记录的MUAP显示时限显著延长，波幅降低。尽管将针移至肌腱附近会增加峰数，但这并不显著。
