Nandedkar S D, Sanders D B
Division of Neurology, Duke University Medical Center, Durham, NC 27710.
Muscle Nerve. 1989 Mar;12(3):197-202. doi: 10.1002/mus.880120306.
Normal motor units (MUs) were simulated and their architecture altered to simulate the changes produced by myopathy. The concentric needle electromyographic recordings of motor unit action potentials (MUAPs) from the MUs were then also simulated. These simulated MUAPs showed features that are seen in myopathy: normal amplitude and slightly reduced area, MUAPs with simple waveform and reduced duration, and complex MUAPs with normal or increased duration. The MUAP waveforms were complex because of increased variability of fiber diameter and not because of loss of muscle fibers. The MUAP duration increased when the variability of fiber diameter increased. Finally, MUAPs similar to those seen in neurogenic diseases were produced from MUs in which the only abnormality was increased variability of fiber diameter.
对正常运动单位（MU）进行模拟，并改变其结构以模拟肌病所产生的变化。然后还模拟了来自这些运动单位的运动单位动作电位（MUAP）的同心针肌电图记录。这些模拟的MUAP显示出肌病中可见的特征：正常幅度和略有减小的面积、波形简单且持续时间缩短的MUAP，以及持续时间正常或增加的复杂MUAP。MUAP波形复杂是由于纤维直径变异性增加，而非肌肉纤维丢失。当纤维直径变异性增加时，MUAP持续时间增加。最后，从仅纤维直径变异性增加这一唯一异常的运动单位中产生了类似于神经源性疾病中所见的MUAP。
