Lee Roland Y, Lin Shuai-Chun, Chen Rebecca I, Barbosa Diego T, Lin Shan C
Department of Ophthalmology, University of California, San Francisco, California, USA Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Department of Ophthalmology, University of California, San Francisco, California, USA.
Br J Ophthalmol. 2016 Sep;100(9):1274-9. doi: 10.1136/bjophthalmol-2015-307393. Epub 2016 Jan 27.
BACKGROUND/AIMS: To evaluate the association between light-to-dark changes in angle width parameters and iris parameters in light, dark and changes from light-to-dark conditions.
In this prospective, cross-sectional study, anterior segment optical coherence tomography images, obtained under light and dark conditions, were analysed to determine angle opening distance measured at 500 μm from the scleral spur (AOD500), trabecular-iris space area at 500 μm from the scleral spur (TISA500), iris thickness measured at 750 μm from the scleral spur (IT750), iris thickness measured at 2000 μm from the scleral spur (IT2000), iris area (IArea) and pupil diameter (PD). Multivariable linear mixed-effect regression models were used to evaluate the association between light-to-dark changes in angle width parameters (AOD500, TISA500) and iris parameters (IT750, IT2000, IArea, PD) in light, dark and changes from light-to-dark conditions.
534 eyes from 314 non-glaucomatous subjects were analysed. IT750, IT2000, IArea and PD in light conditions were significantly associated with light-to-dark changes in AOD500 (p<0.05). IT750, IT2000 and IArea in light conditions were significantly associated with light-to-dark changes in TISA500 (p<0.05). IT750 in dark conditions was significantly associated with light-to-dark changes in AOD500 and TISA500 (p<0.05). Light-to-dark changes in IT2000, IArea and PD were significantly associated with light-to-dark changes in AOD500 (p<0.05). Light-to-dark changes in IArea were significantly associated with light-to-dark changes in TISA500 (p<0.05).
Evaluation of iris parameters in light, dark and changes from light-to-dark conditions demonstrated that IT750, IT2000, IArea and PD in light conditions are significant predictors of light-to-dark changes in angle width.
背景/目的：评估在明、暗及明-暗转换条件下角宽度参数与虹膜参数的明暗变化之间的关联。
在这项前瞻性横断面研究中，对在明、暗条件下获得的眼前节光学相干断层扫描图像进行分析，以确定距巩膜突500μm处的房角开放距离（AOD500）、距巩膜突500μm处的小梁-虹膜空间面积（TISA500）、距巩膜突750μm处的虹膜厚度（IT750）、距巩膜突2000μm处的虹膜厚度（IT2000）、虹膜面积（IArea）和瞳孔直径（PD）。采用多变量线性混合效应回归模型来评估在明、暗及明-暗转换条件下角宽度参数（AOD500、TISA500）与虹膜参数（IT750、IT2000、IArea、PD）的明暗变化之间的关联。
分析了314名非青光眼受试者的534只眼。明视条件下的IT750、IT2000、IArea和PD与AOD500的明暗变化显著相关（p<0.05）。明视条件下的IT750、IT2000和IArea与TISA500的明暗变化显著相关（p<0.05）。暗视条件下的IT750与AOD500和TISA500的明暗变化显著相关（p<0.05）。IT2000、IArea和PD的明暗变化与AOD500的明暗变化显著相关（p<0.05）。IArea的明暗变化与TISA500的明暗变化显著相关（p<0.05）。
在明、暗及明-暗转换条件下对虹膜参数的评估表明，明视条件下的IT750、IT2000、IArea和PD是房角宽度明暗变化的重要预测指标。
