小梁网前后径与前房角宽度之间的关联

Association Between Trabecular Meshwork Anteroposterior Length and Anterior Chamber Angle Width.

作者信息

Lee Roland Y, Lin Shuai-Chun, Chen Rebecca I, Barbosa Diego T, Lin Shan C

机构信息

Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Department of Ophthalmology, University of California, San Francisco, San Francisco, California.

出版信息

Am J Ophthalmol. 2016 Feb;162:53-58.e1. doi: 10.1016/j.ajo.2015.11.007. Epub 2015 Nov 10.

DOI:10.1016/j.ajo.2015.11.007

PMID:26556005

Abstract

PURPOSE

To investigate the association between trabecular meshwork anteroposterior length and anterior chamber angle width in nonglaucomatous subjects.

DESIGN

Prospective, cross-sectional study.

METHODS

Time-domain and spectral-domain anterior segment optical coherence tomography images for 561 eyes from 366 nonglaucomatous subjects were analyzed to determine trabecular meshwork anteroposterior length and 3 anterior chamber angle width parameters measured at different distances from the scleral spur: angle opening distance at 250 μm (AOD250), 500 μm (AOD500), and 750 μm (AOD750) from the scleral spur; trabecular-iris space area at 500 μm (TISA500) and 750 μm (TISA750) from the scleral spur; angle recess area at 750 μm (ARA750) from the scleral spur. Univariable and multivariable linear mixed-effect regression models, the latter adjusting for age, sex, ethnicity, axial length, and the use of both eyes in the same subject, were used to evaluate the association between trabecular meshwork anteroposterior length and anterior chamber angle width parameters.

RESULTS

Mean trabecular meshwork anteroposterior length was 824.86 ± 181.77 μm. Univariate regression analyses showed a significant positive association between trabecular meshwork anteroposterior length and all anterior chamber angle width parameters: AOD250 (P < .001; β = 335.13), AOD500 (P < .001; β = 271.84), AOD750 (P < .001; β = 202.56), TISA500 (P < .001; β = 780.78), TISA750 (P < .001; β = 449.17), ARA750 (P < .001; β = 381.39). Multivariate regression analyses showed a significant positive association between trabecular meshwork anteroposterior length and all anterior chamber angle width parameters: AOD250 (P = .005; β = 294.02), AOD500 (P = .036; β = 172.94), AOD750 (P = .049; β = 125.58), TISA500 (P = .004; β = 611.51), TISA750 (P = .011; β = 333.96), ARA750 (P < .0001; β = 309.12).

CONCLUSIONS

Wider anterior chamber angle is associated with greater trabecular meshwork anteroposterior length.

摘要

目的

研究非青光眼患者小梁网前后径与前房角宽度之间的关系。

设计

前瞻性横断面研究。

方法

分析了366例非青光眼患者561只眼的时域和频域眼前节光学相干断层扫描图像，以确定小梁网前后径以及在距巩膜突不同距离处测量的3个前房角宽度参数：距巩膜突250μm处的房角开放距离（AOD250）、500μm处的房角开放距离（AOD500）和750μm处的房角开放距离（AOD750）；距巩膜突500μm处的小梁-虹膜间隙面积（TISA500）和750μm处的小梁-虹膜间隙面积（TISA750）；距巩膜突750μm处的房角隐窝面积（ARA750）。采用单变量和多变量线性混合效应回归模型（后者对年龄、性别、种族、眼轴长度以及同一受试者双眼的使用情况进行了校正）来评估小梁网前后径与前房角宽度参数之间的关系。

结果

小梁网平均前后径为824.86±181.77μm。单变量回归分析显示，小梁网前后径与所有前房角宽度参数之间均存在显著正相关：AOD250（P<.001；β=335.13）、AOD500（P<.001；β=271.84）、AOD750（P<.001；β=202.56）、TISA500（P<.001；β=780.78）、TISA750（P<.001；β=449.17）、ARA750（P<.001；β=381.39）。多变量回归分析显示，小梁网前后径与所有前房角宽度参数之间均存在显著正相关：AOD250（P=.005；β=294.02）、AOD500（P=.036；β=172.94）、AOD750（P=.049；β=125.58）、TISA500（P=.004；β=611.51）、TISA750（P=.011；β=333.96）、ARA750（P<.0001；β=309.12）。