Institute of Environmental and Occupational Health Sciences, National Yang-Ming University, Taipei, Taiwan.
Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
J Pediatr. 2016 Apr;171:90-6.e1. doi: 10.1016/j.jpeds.2015.12.061. Epub 2016 Jan 23.
To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents.
Adolescents (n = 1454, aged 12-16 years) were assessed in a study conducted to monitor Multilevel Risk Profiles for Adolescent Metabolic Syndrome in Taiwan. Detailed information about demographics, diet, physical, anthropometric, and clinical variables was collected. An original homeostatic model assessment of IR (HOMA1-IR), updated nonlinear homeostatic model assessment of IR (HOMA2-IR) model, and several IR markers were measured.
Adolescents who consumed a greater amount of SSBs were more likely to have elevated fasting serum insulin, HOMA1-IR, and HOMA2-IR (P for trends, ≤.028). Compared with SSB nondrinkers, those with >350 mL/d intake of heavy high-fructose corn syrup-containing SSBs had a 0.52 and 0.30 higher multivariate-adjusted HOMA1-IR and HOMA2-IR, respectively. Waist circumference and serum uric acid were correspondingly found to explain 25.4% and 23.6%, as well as 23.2% and 20.6%, of the increases in the 2 IR markers. Both the elevations of HOMA1-IR and HOMA2-IR for high-fructose corn syrup-rich SSB intake were strengthened among obese adolescents (P for interaction, ≤.033).
Fructose-rich SSB intake is associated with elevated levels of IR, and this relationship may be partially mediated by central adiposity and serum uric acid. Obesity may modify the effect of this type of SSB consumption in intensifying the elevation of IR in adolescents.
确定含糖饮料（SSB）的摄入量与胰岛素抵抗（IR）生物标志物之间的关联，并研究这种关联与青少年肥胖和血清尿酸之间的关系。
在台湾进行的一项监测青少年代谢综合征多层次风险特征的研究中，评估了 1454 名年龄在 12-16 岁的青少年。收集了详细的人口统计学、饮食、身体、人体测量和临床变量信息。测量了原始的稳态模型评估胰岛素抵抗（HOMA1-IR）、更新的非线性稳态模型评估胰岛素抵抗（HOMA2-IR）模型和几种胰岛素抵抗标志物。
摄入更多 SSB 的青少年更有可能出现空腹血清胰岛素、HOMA1-IR 和 HOMA2-IR 升高（趋势 P 值，≤.028）。与 SSB 不饮用者相比，每天摄入>350ml 高果糖玉米糖浆含量的 SSB 者，其多变量校正后的 HOMA1-IR 和 HOMA2-IR 分别高出 0.52 和 0.30。腰围和血清尿酸相应地解释了 25.4%和 23.6%，以及 23.2%和 20.6%的 2 个 IR 标志物的增加。在肥胖青少年中，高果糖玉米糖浆丰富的 SSB 摄入量增加的 HOMA1-IR 和 HOMA2-IR 升高更为明显（交互作用 P 值，≤.033）。
富含果糖的 SSB 摄入量与 IR 水平升高有关，这种关系可能部分通过中心性肥胖和血清尿酸来介导。肥胖可能会改变这种 SSB 消费方式对 IR 升高的强化作用。
