Farhangi Mahdieh Abbasalizad, Nikniaz Zeinab, Mirzohreh Seyedeh-Tarlan, Nikniaz Leila
Department of Community Medicine, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Cardiol Cardiovasc Risk Prev. 2025 Jun 14;26:200453. doi: 10.1016/j.ijcrp.2025.200453. eCollection 2025 Sep.
This study aimed to assess the effects of Sugar-Sweetened Beverages (SSBs) consumption on fasting serum insulin (FSI), fasting plasma glucose (FPG), and HOMA-IR levels among children.
Databases including PubMed/MEDLINE, Scopus, EMBASE, Cochrane Library, and Web of Science were searched up to March 2025. Observational studies reporting the connection of SSBs consumption with FPG, FSI, and HOMA-IR levels were included. STATA version 15 was used to analyze the data.
11 studies with 22,713 subjects were included in this meta-analysis. Greater intake of SSBs was not significantly linked to higher fasting plasma glucose (WMD: 0.01; CI -0.04 -0.07; P = 0.63) and fasting serum insulin levels (WMD: 0.54; 95 % CI, -0.4, 1.49; P = 0.26). However, high SSBs consumption was significantly associated with a 0.21 increase in HOMA-IR in adolescents and children (WMD: 0.21; CI, 0.03-0.37; P = 0.02). In dose-response meta-analysis, no departure from linearity was detected between SSBs intake and changes in FPG, FSI, and HOMA-IR levels.
High SSBs intake was linked to increased HOMA-IR levels among adolescents and children. Further extensive prospective long-term interventions are suggested to confirm the detected associations.
本研究旨在评估儿童饮用含糖饮料（SSB）对空腹血清胰岛素（FSI）、空腹血糖（FPG）和胰岛素抵抗指数（HOMA-IR）水平的影响。
检索截至2025年3月的数据库，包括PubMed/MEDLINE、Scopus、EMBASE、Cochrane图书馆和Web of Science。纳入报告饮用SSB与FPG、FSI和HOMA-IR水平之间关系的观察性研究。使用STATA 15版分析数据。
本荟萃分析纳入了11项研究，共22713名受试者。较高的SSB摄入量与较高的空腹血糖（加权均数差：0.01；可信区间-0.04至-0.07；P = 0.63）和空腹血清胰岛素水平（加权均数差：0.54；95%可信区间，-0.4至1.49；P = 0.26）无显著关联。然而，高SSB摄入量与青少年和儿童的HOMA-IR升高0.21显著相关（加权均数差：0.21；可信区间，0.03至0.37；P = 0.02）。在剂量反应荟萃分析中，未检测到SSB摄入量与FPG、FSI和HOMA-IR水平变化之间存在线性偏离。
高SSB摄入量与青少年和儿童的HOMA-IR水平升高有关。建议进一步开展广泛的前瞻性长期干预，以证实所检测到的关联。
