血清尿酸与新诊断的原发性高血压年轻患者（30-40 岁）的非杓型昼夜节律模式相关。
Serum uric acid is associated with non-dipping circadian pattern in young patients (30-40 years old) with newly diagnosed essential hypertension.
机构信息
a Department of Translational Medical Sciences. Division of Internal Medicine and Cardiac Rehabilitation , "Federico II" University , Naples , Italy .
b Hypertenion Care Unit; "S. Giovanni di Dio e Ruggi d'Aragona" Hospital , Salerno , Italy .
出版信息
Clin Exp Hypertens. 2016;38(2):233-7. doi: 10.3109/10641963.2015.1081230. Epub 2016 Jan 28.
BACKGROUND
We aimed at evaluating the relationship between the circadian blood pressure rhythm and UA level in young patients (30-40 years old) with newly diagnosed essential hypertension.
METHODS
The study included 62 essential hypertensive patients and 29 healthy controls (20 men, 35 ± 3 years) divided into two groups according to 24-hour ABPM results: 30 dippers and 32 nondippers.
RESULTS
Nondippers showed significantly higher both serum UA levels compared to dippers and controls (6.1 ± 0.7, 5.2 ± 0.9 and 4.1 ± 0.9 mg/dL, p < 0.001, respectively); and high sensitivity C-reactive protein (hsCRP) (4.1 ± 2.2 mg/L, 3.3 ± 1.9 mg/L, and 1.4 ± 0.9 mg/L, p < 0.001, respectively). After adjusting for age, sex, body mass index, smoking, creatinine levels, hsCRP and comorbidity, multivariate logistic regression analysis revealed an independent association between serum UA levels and nondipper pattern (OR 2.44, 95%CIs 1.4-4.1, p = 0.002).
CONCLUSION
Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.
背景
本研究旨在评估新诊断的原发性高血压年轻患者（30-40 岁）的昼夜血压节律与 UA 水平之间的关系。
方法
该研究纳入了 62 例原发性高血压患者和 29 名健康对照者（20 名男性，35±3 岁），根据 24 小时 ABPM 结果分为两组：30 例杓型和 32 例非杓型。
结果
非杓型组的血清 UA 水平明显高于杓型组和对照组（6.1±0.7、5.2±0.9 和 4.1±0.9mg/dL，p<0.001）；超敏 C 反应蛋白（hsCRP）（4.1±2.2mg/L、3.3±1.9mg/L 和 1.4±0.9mg/L，p<0.001）也明显更高。在校正年龄、性别、体重指数、吸烟、肌酐水平、hsCRP 和合并症后，多元逻辑回归分析显示，血清 UA 水平与非杓型模式之间存在独立相关性（OR 2.44，95%CI 1.4-4.1，p=0.002）。
结论
血清 UA 与新诊断的原发性高血压年轻患者的非杓型昼夜血压节律独立相关。
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