Zhang Peng, Chen Linjian, Li Zhaokai, Ni Wei, Wang Lin, Mei Wanchun, Ruan Guoqiang, Shi Zaixing, Dai Cuilian
Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xiamen Key Laboratory of Cardiovascular Disease, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Front Cardiovasc Med. 2022 May 17;9:913437. doi: 10.3389/fcvm.2022.913437. eCollection 2022.
Serum uric acid (SUA) levels was associated with cardiovascular diseases and cardiovascular events. However, the relationship between SUA levels and traditional cardiovascular risk factors has not been well-established among Xiamen residents. Our study aimed to estimate the relationship between SUA levels and cardiovascular risk factors among Xiamen residents using real-world data.
Participants were enrolled from eight community health service centers in Xiamen, China. Participants were divided into four groups according to quartiles of the SUA levels. The history of diseases, the use of medications and the levels of laboratory parameters were collected. The China-PAR equation was used to evaluate the 10-year atherosclerotic cardiovascular disease (ASCVD) risk.
A total of 1,322 participants were enrolled. About 568 (43.0%) were men and 754 (57.0%) were women. The prevalences of hypertension, elderly, current smokers, and obesity were higher in the quartile 4 (Q4) group than the quartile 1 (Q1) group (all < 0.001). Multivariable logistic regression analysis showed the OR for hypertension was 2.671 (95% CI 1.777-4.015, < 0.001) in the Q4 group compared with that in the Q1 group. Further logistic regression showed the OR for hypertension was 3.254 (95% CI 1.756-6.031, < 0.001) in men and 2.314 (95% CI 1.354-3.955, = 0.002) in women in the Q4 group compared with that in the Q1 group, respectively. In addition, the percentage of participants with low 10-year ASCVD risk calculated by China-PAR was higher in the Q1 group than that in the Q4 group (55.86 vs. 31.82%, < 0.001). The percentage of participants with high 10-year ASCVD risk was lower in the Q1 group compared with the Q4 group (15.32 vs. 25.45%, < 0.001). Multiple linear logistic regression showed the 10-year China-PAR ASCVD risk scores was positively correlated with SUA after adjusting for various factors (β = 0.135, = 0.001).
Serum uric acid was associated with several cardiovascular risk factors in Xiamen residents. The percentage of high 10-year ASDVD risk was higher in participants with hyperuricemia. Participants with hyperuricemia may experience cardiovascular benefit from uric acid-lowering therapy.
血清尿酸（SUA）水平与心血管疾病及心血管事件相关。然而，在厦门居民中，SUA水平与传统心血管危险因素之间的关系尚未完全明确。我们的研究旨在利用真实世界数据评估厦门居民中SUA水平与心血管危险因素之间的关系。
研究对象来自中国厦门的八个社区卫生服务中心。根据SUA水平的四分位数将参与者分为四组。收集疾病史、用药情况及实验室参数水平。采用中国-PAR方程评估10年动脉粥样硬化性心血管疾病（ASCVD）风险。
共纳入1322名参与者。其中约568名（43.0%）为男性，754名（57.0%）为女性。四分位数4（Q4）组中高血压、老年人、当前吸烟者及肥胖的患病率高于四分位数1（Q1）组（均P<0.001）。多变量逻辑回归分析显示，与Q1组相比，Q�组高血压的OR为2.671（95%CI 1.777-4.015，P<0.001）。进一步的逻辑回归显示，与Q1组相比，Q4组男性高血压的OR为3.254（95%CI 1.756-6.031，P<0.001），女性为2.314（95%CI 1.354-3.955，P=0.002）。此外，通过中国-PAR计算的10年ASCVD低风险参与者百分比在Q1组高于Q4组（55.86%对31.82%，P<0.001）。10年ASCVD高风险参与者百分比在Q1组低于Q4组（15.32%对25.45%，P<0.001）。多元线性逻辑回归显示，在调整各种因素后，10年中国-PAR ASCVD风险评分与SUA呈正相关（β=0.135，P=0.001）。
血清尿酸与厦门居民的多种心血管危险因素相关。高尿酸血症参与者中10年ASDVD高风险百分比更高。高尿酸血症参与者可能从降尿酸治疗中获得心血管益处。
