Ryan Francis Patrick
The Academic Unit of Medical Education, The University of Sheffield, Sheffield, UK.
APMIS. 2016 Jan-Feb;124(1-2):11-9. doi: 10.1111/apm.12488.
The human genome is a holobiontic union of the mammalian nuclear genome, the mitochondrial genome and large numbers of endogenized retroviral genomes. This article defines and explores this symbiogenetic pattern of evolution, looking at the implications for human genetics, epigenetics, embryogenesis, physiology and the pathogenesis of inborn errors of metabolism and many other diseases.
人类基因组是哺乳动物核基因组、线粒体基因组以及大量内源性逆转录病毒基因组的共生联合体。本文定义并探讨了这种共生起源的进化模式，研究其对人类遗传学、表观遗传学、胚胎发生、生理学以及先天性代谢缺陷和许多其他疾病发病机制的影响。
