Kita M, Okawa T, Tanaka M, Ikeda M
Dept. of Radiology, Tokyo Women's Medical College.
Gan No Rinsho. 1989 Sep;35(11):1289-94.
Prospective randomized clinical study was conducted to evaluate the factor of radiation field in radiotherapy for malignant glioma from 1981 to 1988 at Tokyo Women's Medical College. Radiation methods were randomized to two groups; (I) whole brain (40 Gy) and local irradiation (18 Gy), total dose 58 Gy/29 f/6 weeks (TDF 91), (II) local irradiation, total 56 Gy/28 f/6 weeks (TDF 90). Twenty three cases were registered as group I and 26 cases as group II. Two and four years cumulative survival rate were 43% and 17% in group I and 39% and 27% in group II. There were no significant differences on response, survival, recurrent pattern, late effect and complications between whole brain and local irradiation. This study confirmed that local control was the most important in the treatment of malignant glioma.
1981年至1988年，东京女子医科大学开展了一项前瞻性随机临床研究，以评估恶性胶质瘤放疗中照射野因素。放疗方法随机分为两组：（I）全脑照射（40 Gy）加局部照射（18 Gy），总剂量58 Gy/29次/6周（生物效应剂量91），（II）局部照射，总剂量56 Gy/28次/6周（生物效应剂量90）。23例被纳入I组，26例被纳入II组。I组2年和4年累积生存率分别为43%和17%，II组分别为39%和27%。全脑照射与局部照射在反应、生存、复发模式、晚期效应及并发症方面无显著差异。本研究证实，局部控制在恶性胶质瘤治疗中最为重要。
