Nishida Y, Kohno N, Furuya Y, Nakatani T, Kaneko S, Sashikata T, Fujiwara O, Saitoh Y
Dept. of Surgery, Hyogo Medical Center for Adults.
Gan No Rinsho. 1989 Oct;35(12):1461-5.
Discussed is a 33-year-old premenopausal woman who noted a mass in her right breast. On palpation, the tumor was determined as being 3.5 x 2.5 cm in size, well circumscribed, of a firm consistency, and freely movable. Mammography showed a well-defined oval lesion which contained a coarse calcification in the upper external quadrant. An ultrasound study revealed a well-defined oval low echoic lesion with a high echoic portion in the internal echo. The tumor was extirpated and a gross inspection found it to be an ordinary fibroadenoma, 3.2 x 2.5 x 1.5 cm in size. Histologically the lesion was a hyalinized fibroadenoma showing osseous metaplasia. A review of the literature has not revealed cases of a benign breast tumors showing an osseous and/or cartilagenous metaplasia. Notable however is that many reports show mammary osteosarcomas as originating from a fibroadenoma. Thus, this tumor also might have possibly developed into a osteosarcoma.
本文讨论的是一位33岁的绝经前女性,她发现右乳有一个肿块。触诊时,肿瘤大小为3.5×2.5厘米,边界清晰,质地坚硬,可自由移动。乳房X线摄影显示在乳腺外上象限有一个边界清晰的椭圆形病变,其中含有粗大钙化。超声检查显示一个边界清晰的椭圆形低回声病变,内部回声中有一个高回声部分。肿瘤被切除,大体检查发现它是一个普通纤维腺瘤,大小为3.2×2.5×1.5厘米。组织学上,该病变为玻璃样变纤维腺瘤,伴有骨化生。文献回顾未发现良性乳腺肿瘤出现骨和/或软骨化生的病例。然而值得注意的是,许多报告显示乳腺骨肉瘤起源于纤维腺瘤。因此,这个肿瘤也有可能发展成骨肉瘤。