Simi U, Moretti D, Iacconi P, Arganini M, Roncella M, Miccoli P, Giacomini G
Department of Pathology, Spedali Riuniti S. Chiara, Pisa, Italy.
Acta Cytol. 1988 Jan-Feb;32(1):63-6.
The differential diagnosis of benign or borderline phyllodes tumors of the breast in fine needle aspiration biopsy smears was studied. Smears from five histologically proven cases and 20 proven cases of fibroadenoma were evaluated with regard to their cytologic features. The findings indicate that the presence of a high cellularity of stromal fragments (including bipolar naked nuclei), clusters of hyperplastic ductal cells and giant cells and the absence of apocrine metaplasia may suggest a diagnosis of phyllodes tumor, as opposed to fibroadenoma. The borderline phyllodes tumor showed a sarcomatous atypia and/or small intranuclear cytoplasmic invaginations in some cells. The differential diagnosis of this tumor with malignant phyllodes tumor and plasma-cell mastitis is also discussed.
对乳腺细针穿刺活检涂片上的良性或交界性叶状肿瘤进行鉴别诊断研究。对5例经组织学证实的病例以及20例经证实的纤维腺瘤病例的涂片进行细胞学特征评估。结果表明，存在高细胞密度的间质碎片（包括双极裸核）、增生性导管细胞簇和巨细胞，且无大汗腺化生，这可能提示诊断为叶状肿瘤，而非纤维腺瘤。交界性叶状肿瘤表现出肉瘤样异型性和/或部分细胞内有小的核内胞质内陷。还讨论了该肿瘤与恶性叶状肿瘤及浆细胞性乳腺炎的鉴别诊断。
