Vazquez-Vidal Itzel, Chittoor Geetha, Laston Sandra, Puppala Sobha, Kayani Zeeba, Mody Kaizeen, Comuzzie Anthony G, Cole Shelley A, Voruganti V Saroja
Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina.
South Texas Diabetes and Obesity Institute and Regional Academic Health Center, School of Medicine, University of Texas Health Science Center at San Antonio/University of Texas Rio Grande Valley, Harlingen, Texas.
Am J Hum Biol. 2016 May;28(3):440-3. doi: 10.1002/ajhb.22834. Epub 2016 Jan 28.
Genetically isolated and homogenous populations are ideal for detecting genes underlying common complex diseases. The use of isolated populations with reduced disease heterogeneity has led to significant gene discoveries in the past. The aim of this pilot study was to assess the prevalence of cardiovascular disease (CVD) risk phenotypes in a genetically homogenous population of Parsi Zoroastrians in the United States.
Anthropometrics, blood pressure, and medical history were collected from 152 men and 186 women participating in a pilot study as part of the Parsi Family Study. The relative pairs used in the study included 60 parent-off springs, 28 siblings, 6 grandparent-grandchild, 7 avuncular, 18 half-siblings, 7 half-avuncular, and one half-first cousin. Estimates of genetic and environmental influence were calculated using a maximum likelihood-based variance components method implemented in SOLAR.
The prevalence of overweight/obesity in adults (62%) was on par with current US prevalence. Hypertension and prehypertension were prevalent in 16% and 46% of the participants, respectively. The quantitative genetic analysis revealed significant heritabilities for all anthropometric phenotypes (P < 0.05). Significant phenotypic correlations were found between blood pressure and anthropometric phenotypes (P < 0.001), whereas significant genetic correlation was found for only diastolic blood pressure and fat free mass (rhoG = -0.88, P < 0.05).
These preliminary data show significant additive genetic effects on CVD-related phenotypes in this population. Our findings represent the first epidemiological data in Parsi Zoroastrians in the United States and offer excellent promise for future genetic studies in this population. Am. J. Hum. Biol. 28:440-443, 2016. © 2016 Wiley Periodicals, Inc.
基因隔离且同质的人群是检测常见复杂疾病潜在基因的理想对象。过去，利用疾病异质性降低的隔离人群已带来了重大的基因发现。本初步研究的目的是评估美国帕西琐罗亚斯德教徒这一基因同质人群中心血管疾病（CVD）风险表型的患病率。
作为帕西家族研究的一部分，从参与一项初步研究的152名男性和186名女性中收集人体测量数据、血压和病史。该研究中使用的亲属对包括60对父母与子女、28对兄弟姐妹、6对祖父母与孙子女、7对叔侄/舅甥、18对同父异母或同母异父的兄弟姐妹、7对半叔侄/舅甥以及1对同父异母或同母异父的表亲。使用SOLAR中实施的基于最大似然法的方差成分法计算基因和环境影响的估计值。
成年人中超重/肥胖的患病率（62%）与美国当前患病率相当。高血压和高血压前期分别在16%和46%的参与者中普遍存在。定量基因分析显示所有人体测量表型均具有显著的遗传力（P < 0.05）。血压与人体测量表型之间存在显著的表型相关性（P < 0.001），而仅舒张压与去脂体重之间存在显著的基因相关性（rhoG = -0.88，P < 0.05）。
这些初步数据表明该人群中与CVD相关的表型存在显著的加性基因效应。我们的研究结果代表了美国帕西琐罗亚斯德教徒的首批流行病学数据，并为该人群未来的基因研究提供了良好前景。《美国人类生物学杂志》28:440 - 443，2016年。© 2016威利期刊公司
