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在肌钙蛋白水平升高的患者中进行心律监测是否会导致治疗策略的改变?

Does cardiac rhythm monitoring in patients with elevated troponin levels lead to changes in management?

机构信息

1 Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

2 Division of Cardiology, Department of Medicine and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

出版信息

Eur Heart J Acute Cardiovasc Care. 2017 Sep;6(6):545-552. doi: 10.1177/2048872615627709. Epub 2016 Jan 27.

Abstract

BACKGROUND

We sought to identify the frequency of arrhythmias in patients with elevated cardiac troponin levels and without ST-segment elevation myocardial infarction or a primary arrhythmia, and to determine whether detection of an arrhythmia leads to management changes.

METHODS

A review of 1381 consecutive patients admitted from the emergency department for rhythm monitoring with an elevated cardiac troponin T (cTnT) level was performed. Patients admitted to an intensive care unit and those with an initial primary arrhythmia were excluded. Troponin values were obtained on admission, at 3 hours and at 6 hours. Electronic medical records and all rhythm recordings were reviewed for documentation of an arrhythmia and any changes in management.

RESULTS

An arrhythmia was detected in 26% of the 330 patients who met the inclusion criteria. Those with arrhythmias had higher rates of coronary artery disease and prior percutaneous coronary intervention ( p = 0.02 and p = 0.01, respectively). Those with arrhythmias had higher mean cTnT values compared to those without arrhythmias ( p = 0.02 at 3 hours and p = 0.006 at 6 hours) even after controlling for a discharge diagnosis of acute coronary syndrome. Changes in management in response to the detection of arrhythmias were infrequent (6.3%) and usually included only changes in medication doses.

CONCLUSIONS

Patients admitted with an elevated cTnT level to a non-intensive care unit rhythm-monitored bed without ST-segment elevation myocardial infarction or primary arrhythmia have a high incidence of arrhythmias; however, changes in management are infrequent.

摘要

背景

我们旨在确定肌钙蛋白升高且无 ST 段抬高型心肌梗死或原发性心律失常的患者中心律失常的发生率,并确定是否发现心律失常会导致治疗策略的改变。

方法

对因肌钙蛋白 T(cTnT)升高而接受连续心律监测的 1381 例连续入院患者进行了回顾性研究。排除入住重症监护病房和有初始原发性心律失常的患者。入院时、3 小时和 6 小时时获得肌钙蛋白值。对电子病历和所有节律记录进行回顾,以记录心律失常的发生情况和任何治疗策略的改变。

结果

符合纳入标准的 330 例患者中有 26%发现心律失常。有心律失常的患者冠心病和既往经皮冠状动脉介入治疗(PCI)的发生率更高(p=0.02 和 p=0.01)。与无心律失常的患者相比,有心律失常的患者平均 cTnT 值更高(3 小时时 p=0.02,6 小时时 p=0.006),即使在校正急性冠状动脉综合征的出院诊断后也是如此。对心律失常检测结果做出的治疗策略改变并不常见(6.3%),通常仅包括药物剂量的改变。

结论

因肌钙蛋白升高而入住非重症监护病房接受心律监测的病床、且无 ST 段抬高型心肌梗死或原发性心律失常的患者中,心律失常的发生率较高;然而,治疗策略的改变并不常见。

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