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Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

作者信息

Kolwicz Stephen C, Airhart Sophia, Tian Rong

机构信息

From Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (S.C.K., R.T.) and Cardiology Division, Department of Medicine (S.A.), University of Washington, Seattle.

出版信息

Circulation. 2016 Feb 23;133(8):689-91. doi: 10.1161/CIRCULATIONAHA.116.021230. Epub 2016 Jan 27.

DOI:10.1161/CIRCULATIONAHA.116.021230

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4826559/

Abstract

摘要

相似文献

[1]

Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

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[2]

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[3]

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Biochim Biophys Acta Mol Basis Dis. 2020-2-19

[4]

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[5]

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

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[6]

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[7]

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[8]

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[9]

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Curr Heart Fail Rep. 2024-10

[10]

Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism.

Am J Med. 1954-4

引用本文的文献

[1]

Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle.

Cardiovasc Ther. 2025-5-25

[2]

Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations.

Front Pharmacol. 2024-10-24

[3]

Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF.

Circ Res. 2024-10-25

[4]

Nutritional Considerations During Major Weight Loss Therapy: Focus on Optimal Protein and a Low-Carbohydrate Dietary Pattern.

Curr Nutr Rep. 2024-9

[5]

Effects of ketone body 3-hydroxybutyrate on cardiac and mitochondrial function during donation after circulatory death heart transplantation.

Sci Rep. 2024-1-8

[6]

Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction.

Open Med (Wars). 2023-8-31

[7]

Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy.

Metabolites. 2023-8-9

[8]

Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges.

Nat Rev Cardiol. 2023-12

[9]

Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension.

J Am Heart Assoc. 2023-5-16

[10]

Circulating ketone bodies and cardiovascular outcomes: the MESA study.

Eur Heart J. 2023-5-7

本文引用的文献

[1]

The Failing Heart Relies on Ketone Bodies as a Fuel.

Circulation. 2016-2-23

[2]

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Circulation. 2016-2-23

[3]

Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets.

Curr Pharm Des. 2015

[4]

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

Mol Metab. 2014-8-13

[5]

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

Circ Heart Fail. 2014-11

[6]

1H-NMR-based metabolic analysis of human serum reveals novel markers of myocardial energy expenditure in heart failure patients.

PLoS One. 2014-2-5

[7]

Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes.

Circ Res. 2013-8-16

[8]

Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy.

Circ Res. 2012-6-22

[9]

Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure.

Circulation. 2012-5-14

[10]

Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: a report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF).

Am Heart J. 2007-8

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