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局部和远程后适应减轻兔缺血/再灌注模型中的肠损伤。

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model.

作者信息

Yang Mu, Dong Jian-Xin, Li Lu-Bin, Che Hai-Jie, Yong Jun, Song Fu-Bo, Wang Tao, Zhang Jv-Wen

机构信息

Department of Vascular Surgery, Yantai Yuhuangding Hospital, The Affiliated Hospital of Medical College, Qingdao University, Yantai 264000, China.

出版信息

Gastroenterol Res Pract. 2016;2016:2604032. doi: 10.1155/2016/2604032. Epub 2015 Dec 27.

DOI:10.1155/2016/2604032
PMID:26819600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4706963/
Abstract

Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis.

摘要

肠缺血/再灌注（I/R）损伤是一个重大问题，在危急情况下与高发病率和死亡率相关。这种损伤可通过后处理方案得到改善。在我们的研究中，我们创建了一个兔肠I/R损伤模型，以分析局部缺血后处理（LIPo）和远程缺血后处理（RIPo）对肠I/R损伤的影响。我们得出结论，LIPo通过降低氧化应激、中性粒细胞活化和细胞凋亡，以与RIPo相当的方式为肠I/R损伤提供保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/396b10b0428a/GRP2016-2604032.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/179e24bc9e7b/GRP2016-2604032.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/ead4bf810b91/GRP2016-2604032.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/d9bcaa9b5315/GRP2016-2604032.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/396b10b0428a/GRP2016-2604032.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/179e24bc9e7b/GRP2016-2604032.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/ead4bf810b91/GRP2016-2604032.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/d9bcaa9b5315/GRP2016-2604032.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/affc/4706963/396b10b0428a/GRP2016-2604032.004.jpg

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本文引用的文献

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Classical and remote post-conditioning effects on ischemia/reperfusion-induced acute oxidant kidney injury.经典和远程后处理对缺血/再灌注引起的急性氧化应激肾损伤的影响。
Int J Surg. 2014 Nov;12(11):1162-6. doi: 10.1016/j.ijsu.2014.09.007. Epub 2014 Sep 23.
2
Acute mesenteric ischemia.急性肠系膜缺血。
Surg Clin North Am. 2014 Feb;94(1):165-81. doi: 10.1016/j.suc.2013.10.012.
3
Examination of protective effect of ischemic postconditioning after small bowel autotransplantation.小肠自体移植后缺血后处理的保护作用研究
缺血后处理可减少马实验性空肠缺血中的细胞凋亡。
BMC Vet Res. 2021 Apr 26;17(1):175. doi: 10.1186/s12917-021-02877-y.
Transplant Proc. 2010 Jul-Aug;42(6):2287-9. doi: 10.1016/j.transproceed.2010.05.023.
4
Ischemic postconditioning does not attenuate ischemia-reperfusion injury of rabbit small intestine.缺血后处理不能减轻兔小肠缺血再灌注损伤。
Vet Surg. 2010 Feb;39(2):216-23. doi: 10.1111/j.1532-950X.2009.00619.x.
5
Postconditioning protects skeletal muscle from ischemia-reperfusion injury.预处理可保护骨骼肌免受缺血再灌注损伤。
Microsurgery. 2010;30(3):223-9. doi: 10.1002/micr.20756.
6
Evaluation of ischemic postconditioning effect on mesenteric ischemia treatment: experimental study in rats.缺血后处理对肠系膜缺血治疗作用的评估：大鼠实验研究
Rev Bras Cir Cardiovasc. 2009 Apr-Jun;24(2):150-6. doi: 10.1590/s0102-76382009000200010.
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Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.后处理通过激活腺苷受体和蛋白激酶 C 减轻肾缺血再灌注损伤。
Transpl Int. 2010 Feb;23(2):217-26. doi: 10.1111/j.1432-2277.2009.00949.x. Epub 2009 Sep 2.
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